Francois Schweisguth studied at the Ecole Normale Superieure in Paris (1983-88) and obtained a PhD in Developmental Biology in 1990 under the supervision of Jean-Antoine Lepesant (IJM, Paris) and Alain Vincent (CBD, Toulouse). He was a HFSP post-doctoral fellow with Pr. J. W. Posakony at the University of California San Diego (1990-93). He joined the CNRS in 1992, obtained a group leader position (ATIPE-CNRS) at the Ecole Normale Superieure (1996-2008) before joining the Institut Pasteur in 2008 to head a Research Unit. He was awarded a Silver Medal by the CNRS in 2006 and was elected as an EMBO member in 2012. He currently holds a CNRS Research Director position. He headed the CNRS UMR3738 (2011-20) and the BDCS Dept (2016-20), and is currently a co-coordinator of the Labex REVIVE (since 2011) and a co-director of a Pasteur/REVIVE course on Stem Cell Biology (since 2013). His research focuses on the cell biology of Notch, the role of self-organization in the formation of developmental patterns, the control of cell fate and the regulation of epithelial morphogenesis using Drosophila as a model system.
The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]
Epithelia form sheets of interconnected cells that are polarized along an apical-basal axis and perform selective exchange and barrier functions. Epithelia are dynamic structures that undergo remodeling associated with cell shape changes and neighbor […]
Cell polarity and asymmetric cell division
Asymmetric Cell Division (ACD) is a simple and conserved mechanism to generate cell diversity during embryogenesis and throughout adult life. In this process, a mother cell divides to generate two daughter cells with distinct […]
Cell biology of Notch
Cell-cell signaling mediated by Notch receptors regulates a wide range of developmental processes and perturbations of Notch signaling activity underlie various human developmental and adult-onset diseases, including T-cell leukemia and other cancers. Additionally, Notch […]
Stem cells and tissue homeostasis
We have studied together with A. Bardin (Curie Institut) the role of Notch in the regulation of stem cell proliferation and differentiation in the adult fly gut. A. J. Bardin, C. N. Perdigoto, T. […]
Fate patterning and self-organized Notch dynamics
For many developmental processes, the list of the required elements (genes/molecules) is known but the resulting dynamics is often poorly understood. Thus, in most developmental patterning processes, the relative importance of external positional cues […]
Sex, Gamete Compatibility, Pheromones and Endosymbiots
Gamete compatibility is fundamental to sexual reproduction. Wolbachia are maternally inherited endosymbiontic bacteria that manipulate gamete compatibility in many arthropod species. In Drosophila, the fertilization of uninfected eggs by sperm from Wolbachia-infected males often […]
Regulatory genomics – Imogene
Cell fate determination depends in part on the establishment of specific transcriptional programs of gene expression. These programs result from the interpretation of the genomic cis-regulatory information by sequence-specific factors. Decoding this information in […]
Position title : Directeur de Recherche CE CNRS, Unit Head at the Institut Pasteur. Education/Training : 1983-88: Ecole Normale Supérieure, Paris 1996-90: PhD, University Paris 6, Institut Jacques Monod, Lepesant lab. 1990-93: post-doc, University of California San Diego, Posakony lab. Research and Professional Experience :1993-96: Junior Scientist at the CNRS, Institut Jacques Monod (Paris) 1997-2008: ATIP Group Leader, Ecole Normale Supérieure (Paris) 2000- : Directeur de Recherche CNRS 2008- : Head of Unit, Institut Pasteur (Paris) 2010-20: Director of the CNRS Unit URA2578/UMR3738, Institut Pasteur (Paris) 2011- : Co-coordinator of the LabEX Revive 2016-20: Head of the BDCS Dept Honors : Prix Lebrasseur, Fondation de France (2019) Academia Europaea member (2016) Prix Charles-Leopold Mayer, French Academy of Science (2015) EMBO member (2012) Prix Zermati, Fondation de France (2012) Silver Medal of the CNRS (2006) Prix Jaffé, French Academy of Science (2005) Bronze Medal of the CNRS (1996)
2020Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized., J. Cell Biol. 2020 Nov; 219(11): .
2019Optogenetic inhibition of Delta reveals digital Notch signalling output during tissue differentiation, EMBO Rep. 2019 Oct;:e47999.
2019Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila, Nat Commun 2019 Aug;10(1):3486.
2019Activation of Arp2/3 by WASp Is Essential for the Endocytosis of Delta Only during Cytokinesis in Drosophila, Cell Rep 2019 Jul;28(1):1-10.e3.
2019Self-Organization in Pattern Formation, Dev. Cell 2019 Jun;49(5):659-677.
2019Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4, Dev. Cell 2019 May;49(4):556-573.e6.
2019Mechanisms of Notch signaling: a simple logic deployed in time and space, Development 2019 Feb;146(3).
2018Spen limits intestinal stem cell self-renewal, PLoS Genet. 2018 11;14(11):e1007773.
2017Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila, Nat Commun 2017 Nov;8(1):1594.
2017Regulation of cortical stability by RhoGEF3 in mitotic sensory organ precursor cells in Drosophila, Biol Open 2017 Nov;.
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