SEMINAR “Design principles of cell-cell signaling processes” by David Sprinzak
Department of Developmental and Stem Cell Biology 2017 Seminar Series Friday 24th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66) SEMINAR ” Design principles of cell-cell signaling processes “ Invited Speaker ⇒ […]
The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]
Epithelia form sheets of interconnected cells that are polarized along an apical-basal axis and perform selective exchange and barrier functions. Epithelia are dynamic structures that undergo remodeling associated with cell shape changes and neighbor […]
Cell polarity and asymmetric cell division
Asymmetric Cell Division (ACD) is a simple and conserved mechanism to generate cell diversity during embryogenesis and throughout adult life. In this process, a mother cell divides to generate two daughter cells with distinct […]
Cell biology of Notch
Cell-cell signaling mediated by Notch receptors regulates a wide range of developmental processes and perturbations of Notch signaling activity underlie various human developmental and adult-onset diseases, including T-cell leukemia and other cancers. Additionally, Notch […]
Stem cells and tissue homeostasis
The homeostasis of self-renewing tissues relies in part on stem cells. The proliferation and differentiation of stem cells vary with living conditions (temperature, diet, hormones, circadian rhythm, aging, stress, infection…). To study in a […]
Bristle patterning: positional information and self-organization
For many developmental processes, the list of the required elements (genes/molecules) is known but the resulting dynamics is often poorly understood. Thus, in most developmental patterning processes, the relative importance of external positional cues […]
Sex, Gamete Compatibility, Pheromones and Endosymbiots
Gamete compatibility is fundamental to sexual reproduction. Wolbachia are maternally inherited endosymbiontic bacteria that manipulate gamete compatibility in many arthropod species. In Drosophila, the fertilization of uninfected eggs by sperm from Wolbachia-infected males often […]
Regulatory genomics – Imogene
Cell fate determination depends in part on the establishment of specific transcriptional programs of gene expression. These programs result from the interpretation of the genomic cis-regulatory information by sequence-specific factors. Decoding this information in […]
Position title : Directeur de Recherche CE CNRS Director of the CNRS Unit URA2578 Unit Head at the Institut Pasteur Education/Training : 1983-88: Ecole Normale Supérieure, Paris 1996-90: PhD, University Paris 6, Institut Jacques Monod, Lepesant lab. 1990-93: post-doc, University of California San Diego, Posakony lab. Research and Professional Experience : 1993-96: Junior Scientist at the CNRS, Institut Jacques Monod (Paris) 1997-2008: ATIP Group Leader, Ecole Normale Supérieure (Paris) 2000- : Directeur de Recherche CNRS 2008- : Head of Unit, Institut Pasteur (Paris) 2010- : Director of the CNRS Unit URA2578/UMR3738, Institut Pasteur (Paris) 2011- : Co-coordinator of the LabEX Revive Honors : Prix Charles-Leopold Mayer from the French Academy of Science (2015) EMBO member (2012) Prix Zermati from the Fondation de France (2012) Silver Medal of the CNRS (2006) Prix Jaffé from the French Academy of Science (2005) Bronze Medal of the CNRS (1996)
2016Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling, PLoS Genet. 2016 Apr;12(4):e1005984.
2015A Wolbachia-Sensitive Communication between Male and Female Pupae Controls Gamete Compatibility in Drosophila, Curr. Biol. 2015 Sep;25(18):2339-48.
2015Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells, Curr. Biol. 2015 Apr;25(8):1104-10.
2015Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision, Wiley Interdiscip Rev Dev Biol 2015 May-Jun;4(3):299-309.
2014A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo, J. Cell Biol. 2014 Nov;207(3):351-63.
2014Insensible is a novel nuclear inhibitor of Notch activity in Drosophila, PLoS ONE 2014;9(6):e98213.
2014Imogene: identification of motifs and cis-regulatory modules underlying gene co-regulation, Nucleic Acids Res. 2014 Jun;42(10):6128-45.
2014Antibody uptake assay and in vivo imaging to study intracellular trafficking of Notch and Delta in Drosophila, Methods Mol. Biol. 2014;1187:79-86.
2013Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells, Dev. Cell 2013 Aug;26(3):250-65.
2013Inhibition of Notch recycling by Numb: relevance and mechanism(s), Cell Cycle 2013 Jun;12(11):1647-8.
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