Francois Schweisguth studied at the Ecole Normale Superieure in Paris (1983-88) and obtained a PhD in Developmental Biology in 1990 under the supervision of Jean-Antoine Lepesant (IJM, Paris) and Alain Vincent (CBD, Toulouse). He was a HFSP post-doctoral fellow with Pr. J. W. Posakony at the University of California San Diego (1990-93). He joined the CNRS in 1992 and obtained a group leader position (ATIPE-CNRS) at the Ecole Normale Superieure, Biology Dept (Paris) in 1996. He moved to the Institut Pasteur (Paris) to head a Pasteur Unit in 2008. He was awarded a Silver Medal by the CNRS in 2006 and was elected as an EMBO member in 2012. He currently holds a CNRS Research Director position. He is the Director of the CNRS UMR3738 (since 2011), the head of the BDCS Dept (since 2016), a co-coordinator the Labex REVIVE (since 2011) and a co-director of a Pasteur/REVIVE course on Stem Cell Biology (since 2013). His research focuses on the cell biology of Notch, the role of self-organization in the formation of developmental patterns, the control of cell fate and the regulation of epithelial morphogenesis using Drosophila as a model system.
Transversal Projects
Projects
CV
Position title : Directeur de Recherche CE CNRS, Director of the CNRS Unit UMR3738, Head of the BDCS Dept and Unit Head at the Institut Pasteur Education/Training : 1983-88: Ecole Normale Supérieure, Paris 1996-90: PhD, University Paris 6, Institut Jacques Monod, Lepesant lab. 1990-93: post-doc, University of California San Diego, Posakony lab. Research and Professional Experience :1993-96: Junior Scientist at the CNRS, Institut Jacques Monod (Paris) 1997-2008: ATIP Group Leader, Ecole Normale Supérieure (Paris) 2000- : Directeur de Recherche CNRS 2008- : Head of Unit, Institut Pasteur (Paris) 2010- : Director of the CNRS Unit URA2578/UMR3738, Institut Pasteur (Paris) 2011- : Co-coordinator of the LabEX Revive 2016- Head of the BDCS Dept Honors : Academia Europaea member (2016) Prix Charles-Leopold Mayer, French Academy of Science (2015) EMBO member (2012) Prix Zermati, Fondation de France (2012) Silver Medal of the CNRS (2006) Prix Jaffé, French Academy of Science (2005) Bronze Medal of the CNRS (1996)
Publications
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2020Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized., J. Cell Biol. 2020 Nov; 219(11): .
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2019Optogenetic inhibition of Delta reveals digital Notch signalling output during tissue differentiation, EMBO Rep. 2019 Oct;:e47999.
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2019Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila, Nat Commun 2019 Aug;10(1):3486.
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2019Activation of Arp2/3 by WASp Is Essential for the Endocytosis of Delta Only during Cytokinesis in Drosophila, Cell Rep 2019 Jul;28(1):1-10.e3.
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2019Self-Organization in Pattern Formation, Dev. Cell 2019 Jun;49(5):659-677.
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2019Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4, Dev. Cell 2019 May;49(4):556-573.e6.
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2019Mechanisms of Notch signaling: a simple logic deployed in time and space, Development 2019 Feb;146(3).
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2018Spen limits intestinal stem cell self-renewal, PLoS Genet. 2018 11;14(11):e1007773.
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2017Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila, Nat Commun 2017 Nov;8(1):1594.
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2017Regulation of cortical stability by RhoGEF3 in mitotic sensory organ precursor cells in Drosophila, Biol Open 2017 Nov;.
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