Francois Schweisguth studied at the Ecole Normale Superieure in Paris (1983-88) and obtained a PhD in Developmental Biology in 1990 under the supervision of Jean-Antoine Lepesant (IJM, Paris) and Alain Vincent (CBD, Toulouse). He was a HFSP post-doctoral fellow with Pr. J. W. Posakony at the University of California San Diego (1990-93). He joined the CNRS in 1992 and obtained a group leader position (ATIPE-CNRS) at the Ecole Normale Superieure, Biology Dept (Paris) in 1996. He moved to the Institut Pasteur (Paris) to head a Pasteur Unit in 2008. He was awarded a Silver Medal by the CNRS in 2006 and was elected as an EMBO member in 2012. He currently holds a CNRS Research Director position. He is the Director of the CNRS UMR3738 (since 2011), the head of the BDCS Dept (since 2016), a co-coordinator the Labex REVIVE (since 2011) and a co-director of a Pasteur/REVIVE course on Stem Cell Biology (since 2013). His research focuses on the cell biology of Notch, the control of cell fate, the regulation of epithelial morphogenesis and tissue homeostasis using Drosophila as a model system.
The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]
Epithelia form sheets of interconnected cells that are polarized along an apical-basal axis and perform selective exchange and barrier functions. Epithelia are dynamic structures that undergo remodeling associated with cell shape changes and neighbor […]
Cell polarity and asymmetric cell division
Asymmetric Cell Division (ACD) is a simple and conserved mechanism to generate cell diversity during embryogenesis and throughout adult life. In this process, a mother cell divides to generate two daughter cells with distinct […]
Cell biology of Notch
Cell-cell signaling mediated by Notch receptors regulates a wide range of developmental processes and perturbations of Notch signaling activity underlie various human developmental and adult-onset diseases, including T-cell leukemia and other cancers. Additionally, Notch […]
Stem cells and tissue homeostasis
The homeostasis of self-renewing tissues relies in part on stem cells. The proliferation and differentiation of stem cells vary with living conditions (temperature, diet, hormones, circadian rhythm, aging, stress, infection…). To study in a […]
Bristle patterning: positional information and self-organization
For many developmental processes, the list of the required elements (genes/molecules) is known but the resulting dynamics is often poorly understood. Thus, in most developmental patterning processes, the relative importance of external positional cues […]
Sex, Gamete Compatibility, Pheromones and Endosymbiots
Gamete compatibility is fundamental to sexual reproduction. Wolbachia are maternally inherited endosymbiontic bacteria that manipulate gamete compatibility in many arthropod species. In Drosophila, the fertilization of uninfected eggs by sperm from Wolbachia-infected males often […]
Regulatory genomics – Imogene
Cell fate determination depends in part on the establishment of specific transcriptional programs of gene expression. These programs result from the interpretation of the genomic cis-regulatory information by sequence-specific factors. Decoding this information in […]
Position title : Directeur de Recherche CE CNRS, Director of the CNRS Unit UMR3738, Head of the BDCS Dept and Unit Head at the Institut Pasteur
Education/Training : 1983-88: Ecole Normale Supérieure, Paris 1996-90: PhD, University Paris 6, Institut Jacques Monod, Lepesant lab. 1990-93: post-doc, University of California San Diego, Posakony lab.
Research and Professional Experience :1993-96: Junior Scientist at the CNRS, Institut Jacques Monod (Paris) 1997-2008: ATIP Group Leader, Ecole Normale Supérieure (Paris) 2000- : Directeur de Recherche CNRS 2008- : Head of Unit, Institut Pasteur (Paris) 2010- : Director of the CNRS Unit URA2578/UMR3738, Institut Pasteur (Paris) 2011- : Co-coordinator of the LabEX Revive 2016- Head of the BDCS Dept
Honors : Prix Charles-Leopold Mayer from the French Academy of Science (2015) EMBO member (2012) Prix Zermati from the Fondation de France (2012) Silver Medal of the CNRS (2006) Prix Jaffé from the French Academy of Science (2005) Bronze Medal of the CNRS (1996)
2017Cell Polarity and Notch Signaling: Linked by the E3 Ubiquitin Ligase Neuralized?, Bioessays 2017 Nov;39(11).
2017Intra-lineage Fate Decisions Involve Activation of Notch Receptors Basal to the Midbody in Drosophila Sensory Organ Precursor Cells, Curr. Biol. 2017 Aug;27(15):2239-2247.e3.
2017Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms, J. Cell Biol. 2017 May;216(5):1405-1420.
2017Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila, Science 2017 05;356(6337).
2017Response to “Does pupal communication influence Wolbachia-mediated cytoplasmic incompatibility?”, Curr. Biol. 2017 Jan;27(2):R55-R56.
2016Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling, PLoS Genet. 2016 Apr;12(4):e1005984.
2015A Wolbachia-Sensitive Communication between Male and Female Pupae Controls Gamete Compatibility in Drosophila, Curr. Biol. 2015 Sep;25(18):2339-48.
2015Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells, Curr. Biol. 2015 Apr;25(8):1104-10.
2015Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision, Wiley Interdiscip Rev Dev Biol 2015 May-Jun;4(3):299-309.
2014A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo, J. Cell Biol. 2014 Nov;207(3):351-63.
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