Sigolène MEILHAC is a developmental biologist and INSERM Research Director, leading since 2015 the team of Heart Morphogenesis jointly affiliated to the Institut Pasteur and Institut Imagine. Trained at the Ecole Normale Supérieure, she obtained a PhD under the supervision of M. Buckingham (Institut Pasteur) in 2003 and carried out post-doctoral work at the Gurdon Institute of Cambridge (UK), as a Marie Curie and EMBO fellow. She was recruited by the INSERM as a tenured researcher in 2006, and, with the support of the young researcher programme of the ANR in 2012, created a research group at the Institut Pasteur. Now located within the campus of the Hospital Necker-Enfants Malades, her team is part of the « ICaRP cardiology » network, that she coordinates to foster interactions between multi-disciplinary expertise in fundamental research and clinics. She is a member of the Board of Reviewing Editors of the journal eLife. She is involved in academic teaching and student supervision, develops scientific workshops for children. Sigolène Meilhac was recipient of the Pasteur Vallery-Radot price in 2018.
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2024Deep learning-based detection of murine congenital heart defects from µCT scans, bioRxiv.
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2024Notch3 is a genetic modifier of NODAL signalling for patterning asymmetry during mouse heart looping, bioRxiv.
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2024Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice., Nat Commun 2024 Mar; 15(1): 1982.
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2023Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells., Dev Cell 2023 Oct; 58(21).
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2023Origin of congenital coronary arterio-ventricular fistulae from anomalous epicardial and myocardial development., Exp Mol Med 2023 Jan; 55(1): 228-239.
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2022Pseudodynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left–right asymmetry, Nature Cardiovascular Research 2022 ; 1:504–517 .
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20223D cell morphology detection by association for embryo heart morphogenesis, Volume 2 , 2022 , e2.
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2022Shaping the mouse heart tube from the second heart field epithelium, Current Opinion in Genetics and Development, 2022, 73, pp.101896. ⟨10.1016/j.gde.2021.101896⟩.
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2021Heart Development and Congenital Structural Heart Defects., Annu Rev Genomics Hum Genet 2021 08; 22(): 257-284.
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2021Nu3D: 3D Nuclei Segmentation from Light-Sheet Microscopy Images of the Embryonic Heart, 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI).
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