Sigolène MEILHAC is a developmental biologist and INSERM Research Director, leading since 2015 the team of Heart Morphogenesis jointly affiliated to the Institut Pasteur and Institut Imagine. Trained at the Ecole Normale Supérieure, she obtained a PhD under the supervision of M. Buckingham (Institut Pasteur) in 2003 and carried out post-doctoral work at the Gurdon Institute of Cambridge (UK), as a Marie Curie and EMBO fellow. She was recruited by the INSERM as a tenured researcher in 2006, and, with the support of the young researcher programme of the ANR in 2012, created a research group at the Institut Pasteur. Now located within the campus of the Hospital Necker-Enfants Malades, her team is part of the « ICaRP cardiology » network, that she coordinates to foster interactions between multi-disciplinary expertise in fundamental research and clinics. She is a member of the Board of Reviewing Editors of the journal eLife. She is involved in academic teaching and student supervision, develops scientific workshops for children. Sigolène Meilhac was recipient of the Pasteur Vallery-Radot price in 2018.
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2020Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries Shaping the Heart Loop., Dev Cell 2020 Nov; 55(4): 413-431.e6.
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2020Mesoderm patterning by a dynamic gradient of retinoic acid signalling., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2020 Oct; 375(1809): 20190556.
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2020Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis., Cell Rep 2020 Jul; 32(3): 107932.
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2019Standardised imaging pipeline for phenotyping mouse laterality defects and associated heart malformations, at multiple scales and multiple stages., Dis Model Mech 2019 07; 12(7): dmm038356.
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2018Left-right asymmetry in heart development and disease: forming the right loop, Development 2018 Nov;145(22).
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2018The deployment of cell lineages that form the mammalian heart, Nat Rev Cardiol 2018 Nov;15(11):705-724.
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2017A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics., Elife 2017 11; 6:e28951.
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2017Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth, Nat Commun 2017 Feb;8:14582.
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2015The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies, Cilia 2015;4:5.
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2015Imaging and analyzing primary cilia in cardiac cells, Methods Cell Biol. 2015;127:55-73.
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