The Imagine-Institut Pasteur group of Heart Morphogenesis studies how cells are coordinated at the level of the tissue and how their local behaviour generates 3 dimensional changes of organ shape. We address these questions in the context of heart development, using approaches of genetics, transcriptomics, cell biology, 3D imaging, quantitative image analyses and computer modelling. Our study meets novel challenges requiring interdisciplinary efforts, to quantify biological processes or examine the clinical impact of the work. Our work in the mouse is relevant to congenital heart defects and heart repair in humans.
Left-right asymmetry of the heart
Morphogenesis, that is the acquisition of a shape, is essential for organ function. The heart is an asymmetric organ, in which the left and right sides are specified for the establishment of a double […]
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]
The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]
2019Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop, bioRxiv 2019;854463.
2019Standardised imaging pipeline for phenotyping mouse laterality defects and associated heart malformations, at multiple scales and multiple stages, Dis Model Mech 2019 Jun;.
2018Left-right asymmetry in heart development and disease: forming the right loop, Development 2018 Nov;145(22).
2017A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics, Elife 2017 Nov;6.
2017Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth, Nat Commun 2017 Feb;8:14582.
2013Quantitative analysis of polarity in 3D reveals local cell coordination in the embryonic mouse heart, Development 2013 Jan;140(2):395-404.
2004The clonal origin of myocardial cells in different regions of the embryonic mouse heart, Dev. Cell 2004 May;6(5):685-98.
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We are always interested in hearing from students and post-doctoral candidates who are eager to join our team.
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Courriel : sigolene.meilhac[at]pasteur.fr Groupe Imagine-Institut Pasteur – Address : Institut Imagine, 24 boulevard du Montparnasse 75015, Paris France