The Imagine-Institut Pasteur group of Heart Morphogenesis studies how cells are coordinated at the level of the tissue and how their local behaviour generates 3 dimensional changes of organ shape.
We address these questions in the context of heart development, using approaches of genetics, transcriptomics, cell biology, 3D imaging, quantitative image analyses and computer modelling. Our study meets novel challenges requiring interdisciplinary efforts, to quantify biological processes or examine the clinical impact of the work. Our work in the mouse is relevant to congenital heart defects and heart repair in humans.
