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  • Visiting Scientist
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  • Director of Center
  • Director of Department
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About

The Imagine-Institut Pasteur group of Heart Morphogenesis studies how cells are coordinated at the level of the tissue and how their local behaviour generates 3 dimensional changes of organ shape.   Heart development We address these questions in the context of heart development, using approaches of genetics, transcriptomics, cell biology, 3D imaging, quantitative image analyses and computer modelling. Our study meets novel challenges requiring interdisciplinary efforts, to quantify biological processes or examine the clinical impact of the work. Our work in the mouse is relevant to congenital heart defects and heart repair in humans.

Projects

project
Ongoing
5 Members

Left-right asymmetry of the heart

Sigolène Meilhac (PI)

Morphogenesis, that is the acquisition of a shape, is essential for organ function. The heart is an asymmetric organ, in which the left and right sides are specified for the establishment of a double […]
project
Ongoing
5 Members

Mechanism of heart growth

Sigolène Meilhac (PI)

Growth of the heart is required to adapt to the increasing hemodynamic load of the developing organism. Physiologically, heart growth is mainly driven by the proliferation of myocardial cells in utero and by cell […]

Transversal Project

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]

Quantitative biology

The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]

LabEx Revive – Regenerative biology & medicine

  Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. […]

Fundings

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Work with us

We are always interested in hearing from students and post-doctoral candidates who are eager to join our team.

Pictures & Media

2019 Heart Morphogenesis group
2018 Heart Morphogenesis group
2016 Heart Morphogenesis group
2016 Heart Morphogenesis group
2013 Heart Morphogenesis group
2013 Heart Morphogenesis group

Contact

Courriel : sigolene.meilhac[at]pasteur.fr Groupe Imagine-Institut Pasteur – Address : Institut Imagine, 24 boulevard du Montparnasse 75015, Paris France