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About

The Imagine-Institut Pasteur unit of Heart Morphogenesis aims to uncover embryological mechanisms generating the three dimensional shape of the heart and to assess the impact for human diseases. We study how cells are patterned and how coordinated cell behaviour generates 3D tissue deformations to shape the organ.

Heart development

We address these questions using cutting-edge technologies in genetics, omics, 3D imaging, quantitative analyses of complex data and computer simulations. Our study meets novel challenges requiring interdisciplinary efforts in collaboration with computational scientists and clinicians, to quantify biological processes or examine the clinical impact of fundamental knowledge. In the last years, we have developed several tools to image, simulate and quantify heart development and malformation in 3D. Our work in the mouse provides conceptual advances in developmental biology, as well as novel perspectives in human cardiology.

 

Former Members

2000
2000
Name
Position
2009
2015
Chiara Ragni
Graduate Student
2009
2017
Jean-François Le Garrec
Post-doc
2012
2015
Nicolas Diguet
Post-doc
2012
2012
Ewa Zlotek-Zlotkiewicz
Undergraduate Student
2013
2018
Tommaso Lucchesi
Graduate Student
2014
2016
Maryse Brandt
Administrative Staff
2015
2015
Hugo Moisset
Medical student
2015
2017
Risa Kitasato
Clinician
2016
2017
Jing Xie
Research Engineer
2016
2016
Julie Mery-Tahraoui 
Undergraduate Student
2016
2018
Dong Han
Post-doc
2017
2017
Ameya Murukutla
Medical Student
2017
2017
Johanna Lokmer
Medical student
2018
2018
Claire Shea
Post-doc
2018
2018
Nji Asong
Undergraduate Student
2018
2019
Clara Guijarro Calvo
Research Engineer
2018
2019
Héloïse Foucambert Millérioux
Medical student
2019
2020
Sami Chatila
Medical student
Show all

Projects

Transversal Project

Fundings

  • logo FFC

Partners

Featured publications

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Work with us

We are always interested in hearing from students and post-doctoral candidates who are eager to join our team.

Pictures & Media

2019 Heart Morphogenesis group
2018 Heart Morphogenesis group
2016 Heart Morphogenesis group
2016 Heart Morphogenesis group
2013 Heart Morphogenesis group
2013 Heart Morphogenesis group

Contact

Courriel : sigolene.meilhac[at]pasteur.fr Groupe Imagine-Institut Pasteur – Address : Institut Imagine, 24 boulevard du Montparnasse 75015, Paris France