In the last 15 years I have been working in the Department of Developmental and Stem Cell Biology where I have focused my work on skeletal muscles with a particular interest in regenerative myogenesis and the biology of muscle satellite cells. These cells are adult tissue specific stem cells responsible for the lifetime maintenance of the regeneration potential of skeletal muscles.
Directeur de Recherche Institut Pasteur (IP)
a/ Education and work experience
2011-2014 Head of the Laboratory of Molecular Genetics of Development
2002-2011 Senior scientist in the Unit of Molecular Genetics of Development directed by Pr.M.Buckingham. Study of developmental and regenerative myogenesis
2001 Co-founder of the Start up of biotechnology, Celogos, dedicated to cell therapies.
1995-2000 Research position:,Chef de laboratoire (IP). Co-head of the Laboratory of Cell Development.
1986-94 Research position: Chargé de Recherche (IP) Unit of Biochemistry of Pr François Gros. Study of the mechanisms controlling proliferation and differentiation of muscle cells.
1984-1985 Post doc in the laboratory of Pr J.M. Bishop at UCSF. Search for proto-oncogenes in Drosophila Melanogaster.
1983: Doctorat d’Etat ès Sciences Naturelles at the Institut Pasteur. Biochemistry Unit of Pr F. Gros. Mechanisms of the inhibition of muscle cell differentiation by retroviral oncogenes and characterization of new muscle protein isoforms.
1979: First Doctoral Thesis (Doctorat de 3e cycle). University of Paris 7 and Institut Pasteur. Inhibition of muscle cell differentiation by Rous Sarcoma Virus-induced transformation.
2016Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy, Stem Cells 2016 Sep;.
2016Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis, Development 2016 Mar;143(5):872-9.
2014Pitx2 and Pitx3 transcription factors: two key regulators of the redox state in adult skeletal muscle stem cells and muscle regeneration, Free Radic. Biol. Med. 2014 Oct;75 Suppl 1:S37.
2014Redox regulation by Pitx2 and Pitx3 is critical for fetal myogenesis, Dev. Cell 2014 May;29(4):392-405.
2013Lying low but ready for action: the quiescent muscle satellite cell, FEBS J. 2013 Sep;280(17):4036-50.
2013Fetal skeletal muscle progenitors have regenerative capacity after intramuscular engraftment in dystrophin deficient mice, PLoS ONE 2013;8(5):e63016.
2013Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo, PLoS ONE 2013;8(5):e63143.
2013Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse, Development 2013 Mar;140(6):1231-9.
2012Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression, FASEB J. 2012 Nov;26(11):4584-91.
2012Altered in vitro proliferation of mouse SOD1-G93A skeletal muscle satellite cells, Neurodegener Dis 2013;11(3):153-64.
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