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© Research
Publication : The Journal of Cell Biology

Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of Cell Biology - 30 Aug 2019

Bowes C, Redd M, Yousfi M, Tauzin M, Murayama E, Herbomel P

Link to Pubmed [PMID] – 31471458

J. Cell Biol. 2019 Aug;218(10):3258-71

Actin dynamics is central for cells, and especially for the fast-moving leukocytes. The severing of actin filaments is mainly achieved by cofilin, assisted by Aip1/Wdr1 and coronins. We found that in Wdr1-deficient zebrafish embryos, neutrophils display F-actin cytoplasmic aggregates and a complete spatial uncoupling of phospho-myosin from F-actin. They then undergo an unprecedented gradual disorganization of their nucleus followed by eruptive cell death. Their cofilin is mostly unphosphorylated and associated with F-actin, thus likely outcompeting myosin for F-actin binding. Myosin inhibition reproduces in WT embryos the nuclear instability and eruptive death of neutrophils seen in Wdr1-deficient embryos. Strikingly, depletion of the main coronin of leukocytes, coronin 1A, fully restores the cortical location of F-actin, nuclear integrity, viability, and mobility of Wdr1-deficient neutrophils in vivo. Our study points to an essential role of actomyosin contractility in maintaining the integrity of the nucleus of neutrophils and a new twist in the interplay of cofilin, Wdr1, and coronin in regulating F-actin dynamics.

https://www.ncbi.nlm.nih.gov/pubmed/31471458

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