Our research projects articulate around 2 main themes, the identification of new pathogens on one hand, and the resistance of the pathogens in the outside environment on the other hand.
Group : Nathalie Pardigon
Group : Valérie Choumet
Characterization and role of defective viral genomes in the infectious cycle of West Nile (WNV) and Japanese encephalitis (JEV) viruses
This project (part of Divide and ConqueR/INTERCEPT project coordinated by Marco Vignuzzi) pertains to the study, construction and use of defective viral genomes in order to combat viral infections. Neurotropic Flaviviruses, for which no […]
Role of cytoplasmic dynein during Japanese encephalitis virus infectious cycle
This project examines the impact of dynein inhibition on Japanese encephalitis virus (JEV) infectious cycle. Several Flaviviruses (JEV, West Nile virus, yellow fever virus, Zika virus) show alteration of their infectious cycle in the […]
Le projet EBO-SURSY est financé par l’Union Européenne (UE) à hauteur de 8 millions d’euros. Il a été lancé le 15 janvier 2017 dans 10 pays prioritaires pour une période de 5 ans. […]
Neuroinvasiveness of neurotropic Flaviviruses
Flaviviruses such as Japanese encephalitis virus (JEV), West Nile virus (WNV), Yellow Fever virus (YFV) and Zika virus, can infect neuronals cells and cause neuronal damages, when given access to the central nervous system […]
Neural progenitor cell infection by Zika virus in the mouse developing neocortex
Neurotropic flaviviruses are human pathogens responsible for numerous viral encephalitic diseases. West Nile and Japanese encephalitis flaviviruses infect the adult brain and are also responsible for congenital infections that impact fetal brain development. Zika […]
Role of PDZ-binding motif from Flavivirus non-structural proteins in flaviviral life cycle
Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]
KerArbo: Role of salivary factors of Aedes albopictus in the permissiveness of human skin cells to Dengue and Chikungunya viruses
Despite intensive research efforts on arthropod-borne viruses (arboviruses), many aspects related to immunological consequences of arthropod vector-derived salivary factors are unknown, especially those occurring at the injection site. During a blood meal, arboviruses are […]
Metagenomics for Pathogen Detection
Pathogen detection and characterization methods in public health infectious disease surveillance rely on the identification of agents that are already known to be associated with a particular clinical syndrome. Metagenomics, as an emerging field […]
Mutation in Japanese Encephalitis and West Nile virus M protein affects late stages of virus life cycle and pathogenesis.
Flavivirus pre-membrane (prM) protein is important in assembly of viral particles. Its ectodomain is well conserved among flaviviruses. Previous work has shown that expression of this domain can trigger apoptosis in mammalian cells and […]
The European Virus Archive Goes Global
The European Virus Archive now goes global and become EVAg as a continuation of EVA within the Horizon 2020 programme . The new EVAg consortium (25 institution from 19 countries, EU and non-EU ) […]
Groupe Arbovirus (GA) de l’Unité Environnement et Risques Infectieux a été créé en 2014. Le GA travaille sur les virus transmis par les arthropodes (Arbovirus), avec un intérêt pour les arbovirus émergents ou réémergents […]
Summary of the project More than 60% of infectious diseases in humans are caused by pathogens likewise circulating in domestic animals and wildlife. Most of these pathogens are viruses whose genome is an RNA […]
PREDEMICS WorkPackage 1
About PREDEMICS Infectious diseases have always been a threat to the human population, but since the end of World War II, medical progress fostered the hope that pathogens could be controlled if not eradicated […]
Pôle d’Identification Virale (PIV)
Le PIV est le pôle de virologie de la CIBU. Créé depuis 2003, il intervient dans plusieurs domaines : L’investigation de cas cliniques particuliers, à la demande de l’Institut de Veille Sanitaire (InVS), de la […]
Pôle d’Identification Bactérienne (PIB)
Le PIB est le pôle bactériologique de la CIBU de l’Institut Pasteur. Anciennement appelé Centre d’Identification Moléculaire des Bactéries (CIMB), le laboratoire prend le nom de PIB en 2008. La particularité du PIB est […]
Pôle de Génotypage des Pathogènes (PGP)
The Genotyping of Pathogens Pole, the centre for microbial genomics of the Environment and Infectious Risks Research and Expertise Unit, provides skills with genotyping and genomics technologies for the characterization of sensitive pathogens and/or […]
Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions
The use of light from the abyss in biology In the last decades, bioluminescent systems based on the expression of a luciferase and the addition of a luciferin to monitor the emission of […]
Preventing vector-borne diseases around the mediterranean and black sea regions by creating a One Health network of laboratories Countries of the Mediterranean and Black Sea regions share common public health issues and threats. The MediLabSecure […]
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues. Inception program uses Integrative Biology, Social Science […]
2018Innovative in cellulo method as an alternative to in vivo neurovirulence test for the characterization and quality control of human live Yellow Fever virus vaccines: A pilot study, Biologicals 2018 May;53:19-29.
2017Identifying Attenuating Mutations: Tools for a New Vaccine Design against Flaviviruses, Intervirology 2017;60:8-18.
2017Pathophysiological mechanisms of Flavivirus infection of the central nervous system, Transfus Clin Biol 2017 Sep;24(3):96-100.
2016MetaGenSense: A web-application for analysis and exploration of high throughput sequencing metagenomic data, Correia D, Doppelt-Azeroual O, Denis JB et al. MetaGenSense: A web-application for analysis and exploration of high throughput sequencing metagenomic data. F1000Research 2016, 4:86 (doi: 10.12688/f1000research.6139.3) .
2016The growth of arthralgic Ross River virus is restricted in human monocytic cells, Virus Res. 2016 Oct;225:64-68.
2016Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex, EBioMedicine. 2016 Jul 16. pii: S2352-3964(16)30323-1..
2016The E glycoprotein plays an essential role in the high pathogenicity of European-Mediterranean IS98 strain of West Nile virus., Virology. 2016 May;492:53-65. doi: 10.1016/j.virol.2016.02.009. Epub 2016 Feb 19..
2015A Single Amino Acid Substitution in the M Protein Attenuates Japanese Encephalitis Virus in Mammalian Hosts., J Virol. 2015 Dec 9;90(5):2676-89. doi: 10.1128/JVI.01176-15..
2015Infectious Chikungunya Virus in the Saliva of Mice, Monkeys and Humans, PLoS ONE 2015;10(10):e0139481.
2015Biology of Zika Virus Infection in Human Skin Cells, J. Virol. 2015 Sep;89(17):8880-96.
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