I received my Ph.D. in Molecular Chemistry from the Ecole Polytechnique (Palaiseau, France) in 2010 under the supervision of Julia Chamot-Rooke. During this time, I was involved in the development of a top-down mass spectrometry approach combined with hydrogen/deuterium exchange (HDX) for the structural analysis of protein complexes. After my PhD, I joined the proteomics core facility of the Institut Pasteur to work on the Orbitrap Velos ETD coupled with a liquid chromatography. I also manage the high-throughput bottom-up proteomics analysis. I divide my time between the core facility and the Structural Mass Spectrometry and Proteomics Unit headed by Julia Chamot-Rooke, where I am involved in the development of top-down proteomics using high resolution mass spectrometers (Orbitraps).
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2021De Novo Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma., Anal Chem 2021 08; 93(30): 10627-10634.
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2021Advanced In Vivo Cross-Linking Mass Spectrometry Platform to Characterize Proteome-Wide Protein Interactions., Anal Chem 2021 Feb; (): .
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2021Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
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2021Proteomic Analysis of Humoral Immune Components in Bronchoalveolar Lavage of Patients Infected or Colonized by Aspergillus fumigatus., Front Immunol 2021 ; 12(): 677798.
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2020ProteoCombiner: integrating bottom-up with top-down proteomics data for improved proteoform assessment., Bioinformatics 2020 Nov; (): .
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2020Optimization of a Top-Down Proteomics Platform for Closely Related Pathogenic Bacterial Discrimination., J Proteome Res 2020 Oct; (): .
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2020Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape., PLoS Pathog 2020 08; 16(8): e1008822.
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2020The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis., Nat Commun 2020 04; 11(1): 1941.
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2020Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells., EMBO J 2020 04; 39(8): e102166.
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2019Dynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche., Cell Rep 2019 12; 29(12): 3958-3973.e7.
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