Timeline

Christophe Beloin

Group Leader

19 Mar 2024

project

Elucidating envelope evolution and the diderm-to-monoderm transition in Bacteria (ENVOL)

02 Dec 2023

publication

Analysis of in-patient evolution of Escherichia coli reveals potential links to relapse of bone and joint infections.

23 Nov 2023

publication

The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking.

06 Nov 2023

publication

Dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes.

17 Aug 2023

publication

Characterization of Pseudomonas aeruginosa l,d-Transpeptidases and Evaluation of Their Role in Peptidoglycan Adaptation to Biofilm Growth.

17 Aug 2023

publication

Escherichia coli SPFH Membrane Microdomain Proteins HflKC Contribute to Aminoglycoside and Oxidative Stress Tolerance.

03 May 2023

publication

Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties.

11 Apr 2023

publication

Escherichia coli Aggregates Mediated by Native or Synthetic Adhesins Exhibit Both Core and Adhesin-Specific Transcriptional Responses.

16 Mar 2023

publication

Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance.

10 Mar 2023

project

Labex GIL: Methanobrevibacter and Veillonella crosstalk with the intestinal mucosa in the context of health and inflammation

21 Sep 2022

publication

Pseudomonas aeruginosa Production of Hydrogen Cyanide Leads to Airborne Control of Staphylococcus aureus Growth in Biofilm and In Vivo Lung Environments

05 Apr 2022

publication

Selection for nonspecific adhesion is a driver of FimH evolution increasing Escherichia coli biofilm capacity

01 Mar 2022

publication

An ancient divide in outer membrane tethering systems in bacteria suggests a mechanism for the diderm-to-monoderm transition.

28 Sep 2021

project

ANR OM-LipAsy: Outer membrane lipid asymmetry in Veillonella parvula, an atypical diderm Firmicute

14 Jun 2021

event

Seminar DPT Microbiology ” “Using adaptive laboratory evolution to explore the plasticity of biofilm promoting factors and emergence of antibiotic resistance in biofilms”, Christophe Beloin

13 Apr 2021

publication

Lifestyle-specific S-nitrosylation of protein cysteine thiols regulates Escherichia coli biofilm formation and resistance to oxidative stress.

06 Jan 2021

publication

On the strong connection between nanoscale adhesion of Yad fimbriae and macroscale attachment of Yad-decorated bacteria to glycosylated hydrophobic and hydrophilic surfaces

01 Jan 2021

publication

Speciality Grand Challenge for “Biofilms”.

19 Oct 2020

publication

Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition

25 Sep 2020

publication

Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST

17 Aug 2020

publication

Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula

23 Jun 2020

publication

Capsular polysaccharide cross-regulation modulates Bacteroides thetaiotaomicron biofilm formation

23 Jun 2020

publication

Capsular Polysaccharide Cross-Regulation Modulates Bacteroides thetaiotaomicron Biofilm Formation.

23 Jan 2020

publication

One or two membranes? Diderm Firmicutes challenge the Gram-positive/Gram-negative divide

19 Sep 2019

publication

Electrophoresis as a simple method to detect deleterious actions of engineered nanoparticles on living cells

24 May 2019

publication

Zinc acetate potentiates the action of tosufloxacin on Escherichia coli biofilm persisters

04 Mar 2019

publication

A putative type V pilus contributes to Bacteroides thetaiotaomicron biofilm formation capacity

25 Feb 2019

project

Biofilms formed by anaerobes

20 Jul 2018

publication

Increased osmolarity in biofilm triggers RcsB-dependent lipid A palmitoylation in Escherichia coli

01 Jun 2018

publication

Probing the influence of cell surface polysaccharides on nanodendrimer binding to Gram-negative and Gram-positive bacteria using single-nanoparticle force spectroscopy

16 Mar 2018

news

Asymmetric adhesion of rod-shaped bacteria controls microcolony morphogenesis

16 Mar 2018

publication

Asymetric adhesion in rod-shaped bacteria controls microcolony morphogenesis

16 Nov 2017

event

Prof. Michael BOTT – “Corynebacterium glutamicum – microbial cell factory and model organism for actinobacteria”

27 Sep 2017

publication

Comparative Analysis of Bacterial Community Composition and Structure in Clinically Symptomatic and Asymptomatic Central Venous Catheters

12 Sep 2017

publication

YeeJ is an inverse autotransporter from Escherichia coli that binds to peptidoglycan and promotes biofilm formation

10 Sep 2017

publication

Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na2) solution for catheter locks

15 Apr 2017

publication

Central venous catheters and biofilms: where do we stand in 2017?

12 Apr 2017

event

“A novel mechanism of antibiotic resistance in Gram-positive pathogens” By Andrew EDWARDS – Microbiology Departement Seminar

03 Mar 2017

publication

Understanding biofilm formation in intravascular device-related infections

01 Jan 2017

publication

Outer Membrane Proteome of Veillonella parvula: A Diderm Firmicute of the Human Microbiome

19 Dec 2016

project

ANR Fir-OM: Firmicutes with an outer membrane: toward new models to study the diderm/monoderm cell envelope transition

27 Sep 2016

project

PTR OmNega: A multi-disciplinary investigation of the Negativicutes: atypical Firmicutes with LPS-outer membranes that inhabit the human gut

31 Aug 2016

publication

Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes

31 Aug 2016

publication

Functional analysis of Escherichia coli Yad fimbriae reveals their potential role in environmental persistence

23 Jun 2016

publication

Impact of percutaneous pulmonary valve implantation procedural steps on leaflets histology and mechanical behaviour: An in vitro study.

08 Apr 2016

event

Journées du Département de Microbiologie

11 Mar 2016

publication

Study of in vivo catheter biofilm infections using pediatric central venous catheter implanted in rat

16 Sep 2015

course

Microbiology Course Institut Pasteur

10 Sep 2015

course

Institut Pasteur Microbiology Course

06 Aug 2015

tool

Genetic Methods and Tools

06 Aug 2015

tool

In vivo Study of Biofilm-Associated Catheter Infections

02 Aug 2015

project

Biofilm formation

23 Jul 2015

tool

Biofilm Microfermenters

16 Jul 2015

team

Group: Christophe Beloin

06 Jul 2015

publication

Selective propensity of bovine jugular vein material to bacterial adhesions: An in-vitro study.

02 Jul 2015

project

Biofilm physiology

16 Jun 2015

project

Biofilm Tolerance to Antibiotics

11 May 2015

team

Genetics of Biofilms

23 Feb 2015

publication

In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or l-arginine as lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections

14 Feb 2015

publication

Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles.

03 Jan 2015

project

Fighting biofilms

01 Jan 2015

project

Biophysics of Bacteria-Surface Interactions

10 Nov 2014

publication

Dynamic modulation of fimbrial extension and FimH-mannose binding force on live bacteria under pH changes: a molecular atomic force microscopy analysis.

01 Nov 2014

publication

The dynamics and pH-dependence of Ag43 adhesins’ self-association probed by atomic force spectroscopy

23 Sep 2014

publication

Novel approaches to combat bacterial biofilms

01 Sep 2014

publication

Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics

19 Aug 2014

publication

Biofilms formed by gram-negative bacteria undergo increased lipid A palmitoylation enhancing in vivo survival

23 Jul 2014

publication

Bacteria hold their breath upon surface contact as shown in a strain of Escherichia coli, using dispersed surfaces and flow cytometry analysis

15 May 2014

publication

pH-mediated potentiation of aminoglycosides kills bacterial persisters and eradicates in vivo biofilms

01 May 2014

publication

Preventing biofilm formation and associated occlusion by biomimetic glycocalyxlike polymer in central venous catheters

01 Apr 2014

publication

Biofilm tolerance towards antibiotics: Mechanisms and treatment

03 Feb 2014

publication

In Vitro Activities of Dermaseptins K4S4 and K4K20S4 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa Planktonic Growth and Biofilm Formation

01 Feb 2014

publication

Management of infections related to totally implantable venous-access ports: challenges and perspectives

23 Jan 2014

publication

A new biofilm-associated colicin with increased efficiency against biofilm bacteria

20 Dec 2013

publication

Bacterial biofilm mechanical properties persist upon antibiotic treatment and survive cell death

04 Oct 2013

publication

Induction of the Cpx envelope stress pathway contributes to Escherichia coli tolerance to antimicrobial peptides

23 Sep 2013

publication

Sugar-modified foldamers as conformationally defined and biologically distinct glycopeptide mimics.

05 Sep 2013

publication

Did I pick the right colony? Pitfalls in the study of regulation of the phase variable antigen 43 adhesin

13 May 2013

publication

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

07 May 2013

publication

Identification of commensal Escherichia coli genes involved in biofilm resistance to pathogen colonization

21 Mar 2013

publication

Glycan-functionalized diamond nanoparticles as potent E. coli anti-adhesives

03 Jan 2013

publication

Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin

01 Oct 2012

publication

Full and broad-spectrum in vivo eradication of catheter-associated biofilms using gentamicin-EDTA antibiotic lock therapy

19 Sep 2012

publication

Mapping of bacterial biofilm local mechanics by magnetic microparticle actuation

17 Aug 2012

publication

Functional heterogeneity of the UpaH autotransporter protein from uropathogenic Escherichia coli

16 May 2012

publication

A rat model of central venous catheter to study establishment of long-term bacterial biofilm and related acute and chronic infections

27 Jan 2012

publication

Molecular characterization of the EhaG and UpaG trimeric autotransporter proteins from pathogenic Escherichia coli

01 Jan 2012

publication

Molecular characterization of UpaB and UpaC, two new autotransporter proteins of uropathogenic Escherichia coli CFT073

31 May 2011

publication

Bacterial surface appendages strongly impact nanomechanical and electrokinetic properties of Escherichia coli cells subjected to osmotic stress

22 Feb 2011

publication

The sweet connection: Solving the riddle of multiple sugar-binding fimbrial adhesins in Escherichia coli: Multiple E. coli fimbriae form a versatile arsenal of sugar-binding lectins potentially involved in surface-colonisation and tissue tropism

08 Oct 2010

publication

Silent mischief: bacteriophage Mu insertions contaminate products of Escherichia coli random mutagenesis performed using suicidal transposon delivery plasmids mobilized by broad-host-range RP4 conjugative machinery

23 Mar 2010

publication

Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities

26 Aug 2009

publication

Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytes

01 Oct 2008

publication

Impact of rpoS deletion on the proteome of Escherichia coli grown planktonically and as biofilm

01 Jul 2008

publication

A short-time scale colloidal system reveals early bacterial adhesion dynamics

18 Apr 2008

publication

UpaG, a new member of the trimeric autotransporter family of adhesins in uropathogenic Escherichia coli

01 Jan 2008

publication

Escherichia coli biofilms

09 Apr 2007

publication

Functional analysis of antigen 43 in uropathogenic Escherichia coli reveals a role in long-term persistence in the urinary tract

23 Mar 2007

publication

Tight modulation of Escherichia coli bacterial biofilm formation through controlled expression of adhesion factors

01 Feb 2006

publication

The transcriptional antiterminator RfaH represses biofilm formation in Escherichia coli

29 Aug 2005

publication

Colonization of abiotic surfaces

01 Mar 2005

publication

CpxR/OmpR interplay regulates curli gene expression in response to osmolarity in Escherichia coli

15 Feb 2005

publication

Combined inactivation and expression strategy to study gene function under physiological conditions: application to identification of new Escherichia coli adhesins

01 Jan 2005

publication

Finding gene-expression patterns in bacterial biofilms

01 Feb 2004

publication

Global impact of mature biofilm lifestyle on Escherichia coli K-12 gene expression

01 Aug 2003

publication

Shigella flexneri 2a strain 2457T expresses three members of the H-NS-like protein family: characterization of the Sfh protein

19 Jun 2003

publication

In vitro DNA-binding properties of VirB, the Shigella flexneri virulence regulatory protein

01 Jun 2003

publication

Three-way interactions among the Sfh, StpA and H-NS nucleoid-structuring proteins of Shigella flexneri 2a strain 2457T

01 Feb 2003

publication

An extended role for the nucleoid structuring protein H-NS in the virulence gene regulatory cascade of Shigella flexneri

27 Nov 2002

publication

Contribution of DNA conformation and topology in right-handed DNA wrapping by the Bacillus subtilis LrpC protein

15 Feb 2002

publication

Molecular dissection of VirB, a key regulator of the virulence cascade of Shigella flexneri

01 May 2001

publication

Regulation of virulence gene expression in Shigella flexneri, a facultative intracellular pathogen

01 Feb 2001

publication

A possible role for L24 of Bacillus subtilis in nucleoid organization and segregation

01 Aug 2000

publication

Characterization of LrpC DNA-binding properties and regulation of Bacillus subtilis lrpC gene expression

01 Jan 2000

publication

The L17 ribosomal protein of Bacillus subtilis binds preferentially to curved DNA

30 Apr 1998

publication

Chromosomal inactivation of Bacillus subtilis exfusants: a prokaryotic model of epigenetic regulation

01 Sep 1997

publication

Characterization of an lrp-like (lrpC) gene from Bacillus subtilis

15 Nov 1996

publication

Overproduction, purification and characterization of the HPB12-L24 ribosomal protein of Bacillus subtilis.

01 Apr 1996

publication

A little guide for advanced search:

Elucidating envelope evolution and the diderm-to-monoderm transition in Bacteria (ENVOL)

Analysis of in-patient evolution of Escherichia coli reveals potential links to relapse of bone and joint infections.

The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking.

Dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes.

Characterization of Pseudomonas aeruginosa l,d-Transpeptidases and Evaluation of Their Role in Peptidoglycan Adaptation to Biofilm Growth.

Escherichia coli SPFH Membrane Microdomain Proteins HflKC Contribute to Aminoglycoside and Oxidative Stress Tolerance.

Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties.

Escherichia coli Aggregates Mediated by Native or Synthetic Adhesins Exhibit Both Core and Adhesin-Specific Transcriptional Responses.

Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance.

Labex GIL: Methanobrevibacter and Veillonella crosstalk with the intestinal mucosa in the context of health and inflammation

Pseudomonas aeruginosa Production of Hydrogen Cyanide Leads to Airborne Control of Staphylococcus aureus Growth in Biofilm and In Vivo Lung Environments

Selection for nonspecific adhesion is a driver of FimH evolution increasing Escherichia coli biofilm capacity

An ancient divide in outer membrane tethering systems in bacteria suggests a mechanism for the diderm-to-monoderm transition.

ANR OM-LipAsy: Outer membrane lipid asymmetry in Veillonella parvula, an atypical diderm Firmicute

Seminar DPT Microbiology ” “Using adaptive laboratory evolution to explore the plasticity of biofilm promoting factors and emergence of antibiotic resistance in biofilms”, Christophe Beloin

Lifestyle-specific S-nitrosylation of protein cysteine thiols regulates Escherichia coli biofilm formation and resistance to oxidative stress.

On the strong connection between nanoscale adhesion of Yad fimbriae and macroscale attachment of Yad-decorated bacteria to glycosylated hydrophobic and hydrophilic surfaces

Speciality Grand Challenge for “Biofilms”.

Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition

Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST

Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula

Capsular polysaccharide cross-regulation modulates Bacteroides thetaiotaomicron biofilm formation

Capsular Polysaccharide Cross-Regulation Modulates Bacteroides thetaiotaomicron Biofilm Formation.

One or two membranes? Diderm Firmicutes challenge the Gram-positive/Gram-negative divide

Electrophoresis as a simple method to detect deleterious actions of engineered nanoparticles on living cells

Zinc acetate potentiates the action of tosufloxacin on Escherichia coli biofilm persisters

A putative type V pilus contributes to Bacteroides thetaiotaomicron biofilm formation capacity

Biofilms formed by anaerobes

Increased osmolarity in biofilm triggers RcsB-dependent lipid A palmitoylation in Escherichia coli

Probing the influence of cell surface polysaccharides on nanodendrimer binding to Gram-negative and Gram-positive bacteria using single-nanoparticle force spectroscopy

Asymmetric adhesion of rod-shaped bacteria controls microcolony morphogenesis

Asymetric adhesion in rod-shaped bacteria controls microcolony morphogenesis

Prof. Michael BOTT – “Corynebacterium glutamicum – microbial cell factory and model organism for actinobacteria”

Comparative Analysis of Bacterial Community Composition and Structure in Clinically Symptomatic and Asymptomatic Central Venous Catheters

YeeJ is an inverse autotransporter from Escherichia coli that binds to peptidoglycan and promotes biofilm formation

Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na2) solution for catheter locks

Central venous catheters and biofilms: where do we stand in 2017?

“A novel mechanism of antibiotic resistance in Gram-positive pathogens” By Andrew EDWARDS – Microbiology Departement Seminar

Understanding biofilm formation in intravascular device-related infections

Outer Membrane Proteome of Veillonella parvula: A Diderm Firmicute of the Human Microbiome

ANR Fir-OM: Firmicutes with an outer membrane: toward new models to study the diderm/monoderm cell envelope transition

PTR OmNega: A multi-disciplinary investigation of the Negativicutes: atypical Firmicutes with LPS-outer membranes that inhabit the human gut

Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes

Functional analysis of Escherichia coli Yad fimbriae reveals their potential role in environmental persistence

Impact of percutaneous pulmonary valve implantation procedural steps on leaflets histology and mechanical behaviour: An in vitro study.

Journées du Département de Microbiologie

Study of in vivo catheter biofilm infections using pediatric central venous catheter implanted in rat

Microbiology Course Institut Pasteur

Institut Pasteur Microbiology Course

Genetic Methods and Tools

In vivo Study of Biofilm-Associated Catheter Infections

Biofilm formation

Biofilm Microfermenters

Group: Christophe Beloin

Selective propensity of bovine jugular vein material to bacterial adhesions: An in-vitro study.

Biofilm physiology

Biofilm Tolerance to Antibiotics

Genetics of Biofilms

In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or l-arginine as lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections

Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles.

Fighting biofilms

Biophysics of Bacteria-Surface Interactions

Dynamic modulation of fimbrial extension and FimH-mannose binding force on live bacteria under pH changes: a molecular atomic force microscopy analysis.

The dynamics and pH-dependence of Ag43 adhesins’ self-association probed by atomic force spectroscopy

Novel approaches to combat bacterial biofilms

Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics

Biofilms formed by gram-negative bacteria undergo increased lipid A palmitoylation enhancing in vivo survival

Bacteria hold their breath upon surface contact as shown in a strain of Escherichia coli, using dispersed surfaces and flow cytometry analysis

pH-mediated potentiation of aminoglycosides kills bacterial persisters and eradicates in vivo biofilms

Preventing biofilm formation and associated occlusion by biomimetic glycocalyxlike polymer in central venous catheters

Biofilm tolerance towards antibiotics: Mechanisms and treatment

In Vitro Activities of Dermaseptins K4S4 and K4K20S4 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa Planktonic Growth and Biofilm Formation

Management of infections related to totally implantable venous-access ports: challenges and perspectives

A new biofilm-associated colicin with increased efficiency against biofilm bacteria

Bacterial biofilm mechanical properties persist upon antibiotic treatment and survive cell death

Induction of the Cpx envelope stress pathway contributes to Escherichia coli tolerance to antimicrobial peptides

Sugar-modified foldamers as conformationally defined and biologically distinct glycopeptide mimics.

Did I pick the right colony? Pitfalls in the study of regulation of the phase variable antigen 43 adhesin

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections