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© A. Chauhan, JM Ghigo, C. Beloin.
Biofilm formation by Pseudomonas aeruginosa bacteria in Central Venous Catheter. Bacteria are stained in yellow and blood cells in red.
Publication : Pathogens (Basel, Switzerland)

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Pathogens (Basel, Switzerland) - 13 May 2013

Lebeaux D, Chauhan A, Rendueles O, Beloin C

Link to Pubmed [PMID] – 25437038

Pathogens 2013;2(2):288-356

The influence of microorganisms growing as sessile communities in a large number of human infections has been extensively studied and recognized for 30-40 years, therefore warranting intense scientific and medical research. Nonetheless, mimicking the biofilm-life style of bacteria and biofilm-related infections has been an arduous task. Models used to study biofilms range from simple in vitro to complex in vivo models of tissues or device-related infections. These different models have progressively contributed to the current knowledge of biofilm physiology within the host context. While far from a complete understanding of the multiple elements controlling the dynamic interactions between the host and biofilms, we are nowadays witnessing the emergence of promising preventive or curative strategies to fight biofilm-related infections. This review undertakes a comprehensive analysis of the literature from a historic perspective commenting on the contribution of the different models and discussing future venues and new approaches that can be merged with more traditional techniques in order to model biofilm-infections and efficiently fight them.

http://www.ncbi.nlm.nih.gov/pubmed/25437038