Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2022
Ending Date
01
Jan 2025
Status
Ongoing
Members
6
Structures
5

About

Alterations of the gut microbiota are associated with numerous diseases, of which many involve impaired immune tolerance, such as allergies. However, the role of specific microorganisms and underlying molecular mechanisms remain poorly characterised. Archaeal methanogens and the bacterial genus Veillonella are understudied microorganisms of the gut, which possess unique cell structures and metabolism among members of the microbiota. Both microorganisms have been shown to reduce the risk of developing asthma, yet there is a gap of knowledge on how they interact with the host immune responses and its overall physiology. Here, we hypothesize that the methanogen M. smithii (Ms) and the bacteria V. parvula (Vp), are model species with crucial roles in tuning the intestinal mucosa homeostasis and controlling peripheral inflammation, as in allergic asthma. To address this hypothesis, we will first study Ms and Vp physical interactions with the host intestinal cells and characterize their functional impacts. In the second part of the project, we will dissect the crosstalk between Ms and Vp and the host physiology as well as the immune system of the intestinal mucosa. Finally, we will examine how the presence of Ms and Vp in a defined microbiota affects, in vivo, the host homeostasis and immune response in the context of health and allergic asthma. By combining the skills of three laboratories, we will employ an innovative and multidisciplinary approach, which will result in novel basic knowledge on the direct effect of methanogens and Veillonella on the host mucosa, and we will characterise the mechanisms involved. In addition, the project will reveal the potential causality between the presence of these microorganisms and host health, opening new possibilities of precise gut microbiota manipulations in the perspective of preventing and treating diseases.

Fundings