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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Publication : The Journal of infectious diseases

Preventing biofilm formation and associated occlusion by biomimetic glycocalyxlike polymer in central venous catheters

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 01 May 2014

Chauhan A, Bernardin A, Mussard W, Kriegel I, Estève M, Ghigo JM, Beloin C, Semetey V

Link to Pubmed [PMID] – 24795479

J. Infect. Dis. 2014 Nov;210(9):1347-56

The use of catheters and other implanted devices is constantly increasing in modern medicine. Although catheters improve patients’ healthcare, the hydrophobic nature of their surface material promotes protein adsorption and cell adhesion. Catheters are therefore prone to complications, such as colonization by bacterial and fungal biofilms, associated infections, and thrombosis. Here we describe the in vivo efficacy of biologically inspired glycocalyxlike antiadhesive coatings to inhibit Staphylococcus aureus and Pseudomonas aeruginosa colonization on commercial totally implantable venous access ports (TIVAPs) in a clinically relevant rat model of biofilm infection. Although noncoated TIVAPs implanted in rats were heavily colonized by the 2 biofilm-forming pathogens with a high percentage of occlusion, coating TIVAPs reduced their initial adherence and subsequently led to 4-log reduction in biofilm formation and reduced occlusion. Our antiadhesive approach is a simple and generalizable strategy that could be used to minimize clinical complications associated with the use of implantable medical devices.

http://www.ncbi.nlm.nih.gov/pubmed/24795479