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© Research
Event

“A novel mechanism of antibiotic resistance in Gram-positive pathogens” By Andrew EDWARDS – Microbiology Departement Seminar

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
28
Apr 2017
Time
11:30:00
Institut Pasteur, Paris, France
Address
Building: CENTRE FRANCOIS JACOB
Location
2017-04-28 11:30:00 2017-04-28 13:00:00 Europe/Paris “A novel mechanism of antibiotic resistance in Gram-positive pathogens” By Andrew EDWARDS – Microbiology Departement Seminar Andrew M. Edwards PhD Lecturer in Molecular Bacteriology MRC Centre for Molecular Bacteriology and Infection Flowers Building Imperial College London Abstract : Daptomycin is a bactericidal antibiotic of last resort for serious drug-resistant staphylococcal […] Institut Pasteur, Paris, France Christophe Beloin christophe.beloin@pasteur.fr

About

Andrew M. Edwards PhD
Lecturer in Molecular Bacteriology
MRC Centre for Molecular Bacteriology and Infection
Flowers Building
Imperial College London

Abstract :

Daptomycin is a bactericidal antibiotic of last resort for serious drug-resistant staphylococcal infections. Although resistance is rare, treatment failure occurs in up to 30% cases. We have discovered that the frequent loss of the Agr quorum-sensing system in clinical isolates enables S. aureus to survive during daptomycin treatment. Agr-defective mutants release membrane phospholipids in response to daptomycin, which act as decoys by binding and inactivating the antibiotic. Wild-type bacteria also release phospholipid in response to daptomycin, but the Agr-triggered secretion of phenol soluble modulins prevents inactivation of the antibiotic. On-going work seeks to develop new therapeutic strategies that prevent phospholipid release in vivo and provide a clinically-applicable mechanism by which daptomycin therapeutic outcomes can be enhanced.

 

Location

Building: CENTRE FRANCOIS JACOB
Address: Institut Pasteur, Paris, France