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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Publication : Microbiology and molecular biology reviews : MMBR

Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbiology and molecular biology reviews : MMBR - 01 Sep 2014

Lebeaux D, Ghigo JM, Beloin C

Link to Pubmed [PMID] – 25184564

Microbiol. Mol. Biol. Rev. 2014 Sep;78(3):510-43

Surface-associated microbial communities, called biofilms, are present in all environments. Although biofilms play an important positive role in a variety of ecosystems, they also have many negative effects, including biofilm-related infections in medical settings. The ability of pathogenic biofilms to survive in the presence of high concentrations of antibiotics is called “recalcitrance” and is a characteristic property of the biofilm lifestyle, leading to treatment failure and infection recurrence. This review presents our current understanding of the molecular mechanisms of biofilm recalcitrance toward antibiotics and describes how recent progress has improved our capacity to design original and efficient strategies to prevent or eradicate biofilm-related infections.

http://www.ncbi.nlm.nih.gov/pubmed/25184564

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