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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
12
Jun 2015
Ending Date
17
Jun 2020
Status
Ongoing
Members
10
Structures
1
Publications
6

About

bfspeciproper.png

 

BFEXCLAMATION

Specific metabolic changes occurring during biofilm formation were hypothesized to lead to the production of biofilm-associated molecules and biofilm-specific functions. The  identification of biofilm-specific metabolites could reveal new aspects of biofilm biology, and lead to novel strategies to diagnose, fight, or use bacterial biofilms.

Recent articles on this topic

• Szczesny, M., C. Beloin and J.-M. Ghigo (2018). Increased osmolarity in biofilm triggers RcsB-dependent lipid A palmitoylation in Escherichia coli. mBio. Aug 21;9(4). pii: e01415-18. doi: 10.1128/mBio.01415-18.

• Létoffé, S., S. Chalabev, J. Dugay, F. Stressmann, B. Audrain, J.C. Portais, F. Letisse, and J.M. Ghigo. (2017). Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli. PLoS Genetics. May 19;13(5) doi: 10.1371.

Review on this topic

Beloin, C. and J.M. Ghigo. (2005). Finding gene-expression patterns in bacterial biofilms. Trends in Microbiology 13:16-9.

• Ghigo, J.M. (2003). Are there biofilm-specific physiological pathways beyond a reasonable doubt? Research in Microbiology 154:1-8.

References