One of the of the hallmarks of biofilm physiology is its tolerance to a high level of antimicrobials. We are currently investigating the molecular mechanisms that lead to this transient ability to withstand antimicrobial treatments.
Articles on this topic
• Lebeaux, D., V. Leflon-Guibout, J.M. Ghigo, and C. Beloin. (2015). In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or I-arginine as a lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections. The Journal of Antimicrobial Chemotherapy. Jun. 70(6) :1704-12. doi: 10.1093.
• Lebeaux, D., A. Chauhan, S. Létoffé, F. Fischer, H. de Reuse, C. Beloin, and J.M. Ghigo. (2014). pH-mediated potentiation of aminoglycosides kills bacterial persisters and eradicates in vivo biofilms. The Journal of Infectious Diseases Nov. 1;210(9):1357-66. doi: 10.1093.
• Bernier, S., D. Lebeaux, A. DeFrancesco, A. Valomon, G. Soubigou,, J.Y. Coppee, J.M. Ghigo, and C. Beloin. (2013). Starvation, together with the SOS response mediates high and biofilm-specific tolerance to the fluoroquinolone ofloxacin. PLoS Genetics Jan. 9(1):e1003144. doi: 10.1371.
Review on this topic
Lebeaux, D., J.M. Ghigo, and C. Beloin. (2014). Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance towards antibiotics. Microbiology and Molecular Biology Reviews (MMBR)