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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
01
Oct 2021
Ending Date
01
Oct 2024
Status
Ongoing
Members
11
Structures
5

About

The outer membrane (OM) is an essential element in Gram-negative (diderm) bacteria. Its integrity is maintained by the control of lipids asymmetry via LPS and phospholipids transport by the Lpt and Mla systems, respectively. However, outside a few model organisms, it is unknown how this is achieved in most diderm bacteria. In this project, we aim at understanding these processes and their evolution by a powerful combination of experimental and bioinformatics approaches. We will use genetics, functional and structural analyses to dissect the entire process for generation of OM lipid asymmetry in a new experimental model of the bacterial cell envelope, Veillonella parvula, an abundant component of the human microbiome and member of Negativicutes, atypical Firmicutes that strikingly possess a diderm cell envelope with LPS. We will complement these studies by a thorough evolutionary analysis of these transport systems across all Bacteria.

Fundings