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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Publication : The Journal of infectious diseases

pH-mediated potentiation of aminoglycosides kills bacterial persisters and eradicates in vivo biofilms

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 15 May 2014

Lebeaux D, Chauhan A, Létoffé S, Fischer F, de Reuse H, Beloin C, Ghigo JM

Link to Pubmed [PMID] – 24837402

J. Infect. Dis. 2014 Nov;210(9):1357-66

Limitations in treatment of biofilm-associated bacterial infections are often due to subpopulation of persistent bacteria (persisters) tolerant to high concentrations of antibiotics. Based on the increased aminoglycoside efficiency under alkaline conditions, we studied the combination of gentamicin and the clinically compatible basic amino acid L-arginine against planktonic and biofilm bacteria both in vitro and in vivo.

http://www.ncbi.nlm.nih.gov/pubmed/24837402

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