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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
14
Jun 2017
Ending Date
10
Jun 2020
Status
Ongoing
Members
5
Structures
3
Publications
9

About

 Biofilm formation on medical devices is associated with hospital-acquired (nosocomial) infections. Due to biofilms’ high tolerance to antibiotics, classical treatments lack efficacy, and removal of the biofilm-contaminated device is often the only therapeutic option. Hence, control of biofilms is a major concern with important health and economical issues. We developed in vitro and in vivo models to evaluate novel anti-biofilm strategies.

 

 PREVENTING BIOFILM FORMATION

slipperyStudies of bacterial interactions within mixed communities revealed that bacteria produce non-biocidal anti-adhesion polysaccharides. These high-molecular weight polymers alter surface physico-chemical properties and prevent biofilm formation by a wide range of Gram-positive and Gram-negative bacteria. While these studies shed new light on competitive or cooperative behaviors affecting population dynamics, it suggests that anti-adhesion molecules, or other non-biocidal bio-inspired strategies could constitute a therapeutic alternative to limit biofilm formation on medical devices.

 

Recent articles on this topic

• Stressmann, F., E. Couvé-Deacon, D. Chainier, A. Chauhan, A. Wessel, S. Durand-Fontanier, M.C. Escande, I. Kriegel, B. François, M.C. Ploy, C. Beloin, and J.M. Ghigo. (2017). Comparative analysis of bacterial community composition and structure in clinically symptomatic and asymptomatic central venous catheters mSphere. Sep 27;2(5). pii: e00146-17. doi: 10.1128/mSphere.00146-17.

• Khanal, M.#, F. Larsonneur#, V. Raks, A. Barras, J.-S. Baumann, F.A. Martin, R. Boukherroub, J.M. Ghigo, C. Ortiz Mellet, V. Zaitsev, J.M. Garcia Fernandez, C. Beloin*, A..Siriwardena*, and S. Szunerits*. (2015). Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles. Nanoscale Feb 14;7(6): 2325-35. doi: 10.1039. (#equivalent contribution) (*co-corresponding authors).

Review on this topic

Rendueles, O.; Kaplan, J.B. and J.M. Ghigo. (2012). Antibiofilm polysaccharides Minireview. Environmental Microbiology 

Rendueles, O. and J.M. Ghigo. (2012). Multi-species biofilms: How to avoid unfriendly neighbors. FEMS Microbiology Reviews 

ERADICATING BIOFILMS

eradicatingWe developed a clinically relevant in vivo model of catheter-associated biofilm infections to design and test biofilm-eradication approaches applicable to contaminated totally implantable venous access port (TIVAP) catheters. We are currently developing protocols with collaborating clinicians to improve strategies to  reduce the incidence of biofilm-associated infections on TIVAPs.

 

Recent articles on this topic

•  Chauhan, A., J.M. Ghigo, and C. Beloin. (2016). Study of in vivo catheter biofilm infections using pediatric central venous catheter implanted in rat. Nature Protocols Mar;11(3):525-41. doi: 10.1038/nprot.2016.033.

Chauhan A., D. Lebeaux, J.M. Ghigo, and C. Beloin. (2012). Full and broad-spectrum in vivo eradication of catheter-associated biofilms using Gentamicin-EDTA antibiotic lock therapy. Antimicrobial Agents and Chemotherapy 56(12):6310-8. doi: 10.1128.

Review on this topic

• Lebeaux, D., J.M. Ghigo, and C. Beloin. (2014). Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance towards antibiotics Microbiology and Molecular Biology Reviews  Sep. 78(3):510-543. doi: 10.1128.

• Lebeaux, D., N. Fernández-Hidalgo, A. Chauhan, S. Lee, J.M. Ghigo, B. Almirante, and C. Beloin. (2014). Management of infections related to totally implantable venous-access ports: challenges and perspectives. The Lancet Infectious Diseases Feb. 14(2):146-59. doi: 10.1016

 


References