Timeline
Philippe Sansonetti
Head of Structure
01 Dec 2023
publication
Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes.
Read more09 Oct 2023
11 Oct 2022
publication
Stunted children display ectopic small intestinal colonization by oral bacteria, which cause lipid malabsorption in experimental models.
Read more12 Aug 2022
publication
Putative Biomarkers of Environmental Enteric Disease Fail to Correlate in a Cross-Sectional Study in Two Study Sites in Sub-Saharan Africa.
Read more27 Apr 2022
publication
The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella.
Read more11 Mar 2022
publication
Detection of Streptococcus gallolyticus and Four Other CRC- Associated Bacteria in Patient Stools Reveals a Potential “Driver” Role for Enterotoxigenic Bacteroides fragilis
Read more02 Jan 2022
publication
Changes in Systemic Regulatory T Cells, Effector T Cells, and Monocyte Populations Associated With Early-Life Stunting.
Read more01 Jan 2022
publication
Detection of Streptococcus gallolyticus and Four Other CRC-Associated Bacteria in Patient Stools Reveals a Potential “Driver” Role for Enterotoxigenic Bacteroides fragilis.
Read more29 Apr 2021
publication
Structural Insights of Shigella Translocator IpaB and Its Chaperone IpgC in Solution.
Read more31 Jul 2020
08 May 2020
22 Feb 2020
01 Jan 2020
01 Oct 2019
publication
Mapping of Shigella flexneri’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs
Read more03 Sep 2019
publication
Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection
Read more02 Jul 2019
publication
Shigella promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport.
Read more28 Mar 2019
07 Dec 2018
25 Aug 2018
patent
Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri (SF6)
Read more25 Aug 2018
patent
Glycoconjugates and use thereof as vaccines against Shigella flexneri serotype 3a and X
Read more25 Aug 2018
patent
Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri
Read more19 Apr 2018
24 Jan 2018
event
“Epithelial cell migration in gut homeostasis and cancer invasion” – by Danijela Vignjevic
Read more26 Dec 2017
07 Dec 2017
event
“Salmonella diarrhea: growth, gene transfer and mutations to escape the host’s immune response” – Wolf-Dietrich Hardt
Read more14 Jun 2017
publication
Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy
Read more06 Apr 2017
event
EMBO Conference on Hijacking host signalling and epigenetic mimicry during infections
Read more10 Jan 2017
project
MITICA: Identifying the mechanisms of acquisition of a dysbiotic microbiota and pediatric environmental enteropathy in infants in the context of chronic malnutrition
Read more07 Nov 2016
08 Jul 2016
27 Mar 2016
22 Mar 2016
project
Phylogenomics of Shiga’s epidemic dysentery bacillus (Shigella dysenteriae type 1)
Read more27 Oct 2015
10 Jul 2015
04 Jun 2015
26 May 2015
publication
Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA
Read more26 May 2015
publication
Streptococcus gallolyticus Pil3 Pilus Is Required for Adhesion to Colonic Mucus and for Colonization of Mouse Distal Colon
Read more13 May 2015
publication
Functional Genomic Screen Identifies Klebsiella pneumoniae Factors Implicated in Blocking Nuclear Factor κB (NF-κB) Signaling
Read more26 Mar 2015
publication
Distinct mutations led to inactivation of type 1 fimbriae expression in Shigella spp
Read more20 Mar 2015
09 Feb 2015
publication
Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance
Read more09 Feb 2015
19 Jan 2015
15 Jan 2015
publication
Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton
Read more14 Jan 2015
12 Sep 2014
publication
Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF
Read more04 Sep 2014
publication
The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling
Read more01 Sep 2014
16 Aug 2014
publication
Rapid 96-well plates DNA extraction and sequencing procedures to identify genome-wide transposon insertion sites in a difficult to lyse bacterium: Lactobacillus casei
Read more05 Aug 2014
publication
Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri
Read more14 Jul 2014
28 Jun 2014
publication
Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity
Read more02 Jun 2014
29 May 2014
publication
The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration
Read more22 May 2014
21 Apr 2014
publication
The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa
Read more06 Mar 2014
04 Mar 2014
publication
ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics
Read more12 Feb 2014
publication
A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread
Read more12 Dec 2013
publication
A Shigella effector dampens inflammation by regulating epithelial release of danger signal ATP through production of the lipid mediator PtdIns5P
Read more22 Nov 2013
publication
Rapid diagnosis of diarrhea caused by Shigella sonnei using dipsticks; comparison of rectal swabs, direct stool and stool culture
Read more01 Nov 2013
publication
The synergies of microorganisms enlightened – convergent approaches to delineating coinfections
Read more24 Oct 2013
22 Jul 2013
publication
Virulent Shigella flexneri affects secretion, expression, and glycosylation of gel-forming mucins in mucus-producing cells
Read more12 Jun 2013
publication
Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.
Read more30 Apr 2013
publication
Epithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve
Read more01 Apr 2013
publication
A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes
Read more15 Feb 2013
01 Jan 2013
01 Jan 2013
10 Dec 2012
01 Dec 2012
13 Sep 2012
publication
Shigella effector IpaB-induced cholesterol relocation disrupts the Golgi complex and recycling network to inhibit host cell secretion
Read more24 Aug 2012
publication
The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak
Read more06 Aug 2012
publication
Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers
Read more04 Jun 2012
publication
Quantitative RT-PCR profiling of the rabbit immune response: assessment of acute Shigella flexneri infection
Read more22 May 2012
18 May 2012
publication
Development of an efficient in vivo system (Pjunc-TpaseIS1223) for random transposon mutagenesis of Lactobacillus casei
Read more23 Apr 2012
publication
Hierarchies of host factor dynamics at the entry site of Shigella flexneri during host cell invasion
Read more16 Mar 2012
publication
Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain
Read more15 Mar 2012
publication
Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium’s epithelial niche
Read more12 Mar 2012
publication
Characterization of the promoter, MxiE box and 5′ UTR of genes controlled by the activity of the type III secretion apparatus in Shigella flexneri
Read more01 Mar 2012
01 Jan 2012
03 Oct 2011
publication
Dipstick test for rapid diagnosis of Shigella dysenteriae 1 in bacterial cultures and its potential use on stool samples
Read more20 Sep 2011
publication
Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling
Read more03 Aug 2011
publication
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Read more16 Jun 2011
publication
ATP-mediated Erk1/2 activation stimulates bacterial capture by filopodia, which precedes Shigella invasion of epithelial cells
Read more24 May 2011
publication
PCR-based identification of Klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma
Read more21 Apr 2011
publication
The Shigella flexneri type three secretion system effector IpgD inhibits T cell migration by manipulating host phosphoinositide metabolism.
Read more28 Feb 2011
01 Feb 2011
19 Dec 2010
publication
Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract
Read more07 Dec 2010
publication
Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione
Read more30 Oct 2010
publication
Safety, dose, immunogenicity, and transmissibility of an oral live attenuated Shigella flexneri 2a vaccine candidate (SC602) among healthy adults and school children in Matlab, Bangladesh
Read more01 Aug 2010
02 May 2010
11 Jan 2010
publication
Tracking the dynamic interplay between bacterial and host factors during pathogen-induced vacuole rupture in real time
Read more21 Dec 2009
publication
Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control
Read more27 Nov 2009
14 Oct 2009
publication
Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits
Read more20 Aug 2009
publication
Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy
Read more01 Aug 2009
01 Jul 2009
publication
Framing a concept and an agenda for infectious diseases in EMBO Molecular Medicine
Read more01 May 2009
01 Apr 2009
publication
WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics.
Read more05 Mar 2009
publication
Characterisation of early mucosal and neuronal lesions following Shigella flexneri infection in human colon
Read more19 Feb 2009
15 Feb 2009
publication
A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection
Read more23 Jan 2009
publication
The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells
Read more09 Jan 2009
publication
Safety and immunogenicity of SC599, an oral live attenuated Shigella dysenteriae type-1 vaccine in healthy volunteers: results of a Phase 2, randomized, double-blind placebo-controlled trial
Read more01 Dec 2008
publication
Rhinoscleroma: a French national retrospective study of epidemiological and clinical features
Read more09 Nov 2008
publication
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases
Read more10 Oct 2008
publication
[“Neglected diseases”: it is better to respond to future challenges–the model of a pilot North-South program on enteric infections integrating many research components]
Read more10 Jul 2008
publication
Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?
Read more01 Jul 2008
12 Jun 2008
publication
Commensals, bacterial pathogens and intestinal inflammation: an intriguing ménage à trois
Read more21 Apr 2008
publication
Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression
Read more01 Apr 2008
publication
War and peace at the intestinal epithelial surface: an integrated view of bacterial commensalism versus bacterial pathogenicity
Read more01 Apr 2008
publication
Maturation of paneth cells induces the refractory state of newborn mice to Shigella infection
Read more15 Mar 2008
publication
Delivery of biologically active anti-inflammatory cytokines IL-10 and IL-1ra in vivo by the Shigella type III secretion apparatus
Read more15 Feb 2008
publication
SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases
Read more28 Jan 2008
11 Jan 2008
publication
Extracellular-loop peptide antibodies reveal a predominant hemichannel organization of connexins in polarized intestinal cells
Read more10 Jan 2008
publication
Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella
Read more08 Dec 2007
publication
IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri
Read more03 Dec 2007
publication
Phase 1 clinical trial of live attenuated Shigella dysenteriae type-1 DeltaicsA Deltaent Deltafep DeltastxA:HgR oral vaccine SC599 in healthy human adult volunteers
Read more12 Nov 2007
publication
Molecular and cellular bases of bacterial virulence: guessing the future episodes of an ongoing saga
Read more05 Nov 2007
publication
Roundtrip explorations of bacterial infection: from single cells to the entire host and back
Read more26 Oct 2007
publication
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction
Read more14 Jun 2007
publication
Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy
Read more18 Apr 2007
01 Apr 2007
15 Mar 2007
01 Mar 2007
publication
[Shigella flexneri modulates host cell epigenetic information as a strategy to shape the transcriptional response]
Read more15 Feb 2007
publication
New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies
Read more02 Feb 2007
publication
Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain
Read more01 Feb 2007
09 Jan 2007
publication
Shigella’s ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?
Read more11 Dec 2006
10 Dec 2006
publication
An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses
Read more01 Dec 2006
24 Oct 2006
publication
Transcriptional slippage controls production of type III secretion apparatus components in Shigella flexneri
Read more18 Oct 2006
publication
IpaD is localized at the tip of the Shigella flexneri type III secretion apparatus
Read more01 Sep 2006
01 Aug 2006
01 Mar 2006
publication
Rupture, invasion and inflammatory destruction of the intestinal barrier by Shigella: the yin and yang of innate immunity
Read more01 Mar 2006
16 Feb 2006
publication
PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection
Read more01 Feb 2006
publication
Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine
Read more15 Jan 2006
publication
Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells
Read more01 Jan 2006
publication
Specific host genes required for the killing of Klebsiella bacteria by phagocytes
Read more01 Jan 2006
01 Dec 2005
publication
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
Read more18 Nov 2005
19 Sep 2005
publication
Identification of the critical residues involved in peptidoglycan detection by Nod1
Read more14 Sep 2005
publication
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes
Read more22 Aug 2005
publication
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
Read more01 Aug 2005
01 Aug 2005
publication
Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells
Read more01 Jun 2005
publication
A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri
Read more31 May 2005
publication
Mucosal lymphoid infiltrate dominates colonic pathological changes in murine experimental shigellosis
Read more01 Apr 2005
publication
Frameshifting by transcriptional slippage is involved in production of MxiE, the transcription activator regulated by the activity of the type III secretion apparatus in Shigella flexneri
Read more25 Feb 2005
01 Feb 2005
publication
Tyrosine kinase signaling and type III effectors orchestrating Shigella invasion
Read more01 Jan 2005
publication
Adherence modifies the regulation of gene expression induced by interleukin-10
Read more01 Dec 2004
17 Oct 2004
publication
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Read more15 Sep 2004
publication
IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis
Read more19 Jul 2004
publication
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells
Read more01 Jun 2004
01 May 2004
publication
Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo
Read more01 Apr 2004
01 Apr 2004
01 Feb 2004
01 Dec 2003
publication
Lessons from Nod2 studies: towards a link between Crohn’s disease and bacterial sensing
Read more01 Aug 2003
publication
Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells
Read more18 Jul 2003
01 Jul 2003
17 Jun 2003
publication
The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco-2
Read more01 Jun 2003
publication
Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells
Read more01 Apr 2003
publication
Shigella interaction with intestinal epithelial cells determines the innate immune response in shigellosis
Read more07 Mar 2003
publication
Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases
Read more13 Jan 2003
publication
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
Read more01 Dec 2002
publication
Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri
Read more01 Oct 2002
publication
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology
Read more01 Sep 2002
publication
Epithelial inflammation response induced by Shigella flexneri depends on mucin gene expression
Read more01 Sep 2002
publication
Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction
Read more01 Jul 2002
publication
Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo
Read more01 Jul 2002
publication
Human monocytes kill Shigella flexneri but then die by apoptosis associated with suppression of proinflammatory cytokine production
Read more01 Jun 2002
publication
The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model
Read more01 Jun 2002
publication
Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2
Read more15 May 2002
publication
Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium
Read more01 May 2002
01 May 2002
publication
Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells
Read more01 Apr 2002
publication
Intracellular vs extracellular recognition of pathogens–common concepts in mammals and flies
Read more01 Mar 2002
publication
Regulation of transcription by the activity of the Shigella flexneri type III secretion apparatus
Read more01 Mar 2002
publication
Spa15 of Shigella flexneri, a third type of chaperone in the type III secretion pathway
Read more30 Jan 2002
publication
The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells
Read more01 Jul 2000
publication
The interplay between receptor capping and cytoskeleton remodeling in Entamoeba histolytica
Read more01 May 2000
publication
Cell polarization and adhesion in a motile pathogenic protozoan: role and fate of the Entamoeba histolytica Gal/GalNAc lectin
Read more01 Jul 1999
01 Apr 1999
publication
Myosin IB from Entamoeba histolytica is involved in phagocytosis of human erythrocytes
Read more01 Jun 1998
publication
Virulence and functions of myosin II are inhibited by overexpression of light meromyosin in Entamoeba histolytica
Read more01 Jun 1998
publication
The small GTP-binding protein RacG regulates uroid formation in the protozoan parasite Entamoeba histolytica
Read more01 Oct 1997
publication
Interaction between Entamoeba histolytica and intestinal epithelial cells involves a CD44 cross-reactive protein expressed on the parasite surface
Read more01 May 1997
publication
Molecular characterization of myosin IB from the lower eukaryote Entamoeba histolytica, a human parasite
Read more01 Jan 1997
01 Jan 1997
publication
Rac G, a small GTPase, regulates capping of surface receptors in Entamoeba histolytica
Read more01 Dec 1996
publication
Identification and cellular localization of the actin-binding protein ABP-120 from Entamoeba histolytica
Read more01 Nov 1995
publication
Myosin II is involved in capping and uroid formation in the human pathogen Entamoeba histolytica
Read more01 May 1993
publication
Identification and characterization of a myosin heavy chain gene (mhcA) from the human parasitic pathogen Entamoeba histolytica
Read more01 Mar 1993
publication
Localization of myosin heavy chain A in the human pathogen Entamoeba histolytica
Read more01 Jan 1992