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  • Deputy Head of Facility
  • Director of Center
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© Research
Publication : Best practice & research. Clinical gastroenterology

Microbial-gut interactions in health and disease. Epithelial cell responses

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Best practice & research. Clinical gastroenterology - 01 Apr 2004

Mavris M, Sansonetti P

Link to Pubmed [PMID] – 15123076

Best Pract Res Clin Gastroenterol 2004 Apr;18(2):373-86

Pathogenic bacteria use many strategies to secure their survival within the host. Enteropathogens exploit intestinal epithelial cells in many ways, including the manipulation of normal cellular functioning, or of cellular structural components, or by the induction of signalling pathways, such as the production of pro-inflammatory cytokines. However, the enterocyte warns the host of impending danger and, in turn, elicits a protective response. Pathogens are detected by epithelial cells owing to their vast array of surface antigens and secreted products. Epithelial cells have developed both extracellular and intracellular sensing proteins that function as a first line of defence against pathogens; this is followed by acquired immunity, namely IgA, which is used as reinforcement. Thus, in a game of constant attack and defence, the pathogen and the enterocyte aim to outsmart each other in an effort to survive.