Ligne de temps
Philippe Sansonetti
Responsable de Structure
01 déc. 2023
publication
Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes.
Lire plus09 oct. 2023
11 oct. 2022
publication
Stunted children display ectopic small intestinal colonization by oral bacteria, which cause lipid malabsorption in experimental models.
Lire plus12 août 2022
publication
Putative Biomarkers of Environmental Enteric Disease Fail to Correlate in a Cross-Sectional Study in Two Study Sites in Sub-Saharan Africa.
Lire plus27 avr. 2022
publication
The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella.
Lire plus11 mars 2022
publication
Detection of Streptococcus gallolyticus and Four Other CRC- Associated Bacteria in Patient Stools Reveals a Potential “Driver” Role for Enterotoxigenic Bacteroides fragilis
Lire plus02 janv. 2022
publication
Changes in Systemic Regulatory T Cells, Effector T Cells, and Monocyte Populations Associated With Early-Life Stunting.
Lire plus01 janv. 2022
publication
Detection of Streptococcus gallolyticus and Four Other CRC-Associated Bacteria in Patient Stools Reveals a Potential “Driver” Role for Enterotoxigenic Bacteroides fragilis.
Lire plus29 avr. 2021
publication
Structural Insights of Shigella Translocator IpaB and Its Chaperone IpgC in Solution.
Lire plus31 juil. 2020
08 mai 2020
22 févr. 2020
01 janv. 2020
01 oct. 2019
publication
Mapping of Shigella flexneri’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs
Lire plus03 sept. 2019
publication
Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection
Lire plus02 juil. 2019
publication
Shigella promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport.
Lire plus28 mars 2019
07 déc. 2018
25 août 2018
patent
Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri (SF6)
Lire plus25 août 2018
patent
Glycoconjugates and use thereof as vaccines against Shigella flexneri serotype 3a and X
Lire plus25 août 2018
patent
Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri
Lire plus19 avr. 2018
24 janv. 2018
event
“Epithelial cell migration in gut homeostasis and cancer invasion” – by Danijela Vignjevic
Lire plus26 déc. 2017
07 déc. 2017
event
“Salmonella diarrhea: growth, gene transfer and mutations to escape the host’s immune response” – Wolf-Dietrich Hardt
Lire plus14 juin 2017
publication
Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy
Lire plus06 avr. 2017
event
EMBO Conference on Hijacking host signalling and epigenetic mimicry during infections
Lire plus10 janv. 2017
project
MITICA: Identifying the mechanisms of acquisition of a dysbiotic microbiota and pediatric environmental enteropathy in infants in the context of chronic malnutrition
Lire plus07 nov. 2016
08 juil. 2016
27 mars 2016
22 mars 2016
project
Phylogenomics of Shiga’s epidemic dysentery bacillus (Shigella dysenteriae type 1)
Lire plus27 oct. 2015
10 juil. 2015
04 juin 2015
26 mai 2015
publication
Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA
Lire plus26 mai 2015
publication
Streptococcus gallolyticus Pil3 Pilus Is Required for Adhesion to Colonic Mucus and for Colonization of Mouse Distal Colon
Lire plus13 mai 2015
publication
Functional Genomic Screen Identifies Klebsiella pneumoniae Factors Implicated in Blocking Nuclear Factor κB (NF-κB) Signaling
Lire plus26 mars 2015
publication
Distinct mutations led to inactivation of type 1 fimbriae expression in Shigella spp
Lire plus20 mars 2015
09 févr. 2015
publication
Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance
Lire plus09 févr. 2015
19 janv. 2015
15 janv. 2015
publication
Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton
Lire plus14 janv. 2015
12 sept. 2014
publication
Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF
Lire plus04 sept. 2014
publication
The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling
Lire plus01 sept. 2014
16 août 2014
publication
Rapid 96-well plates DNA extraction and sequencing procedures to identify genome-wide transposon insertion sites in a difficult to lyse bacterium: Lactobacillus casei
Lire plus05 août 2014
publication
Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri
Lire plus14 juil. 2014
28 juin 2014
publication
Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity
Lire plus02 juin 2014
29 mai 2014
publication
The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration
Lire plus22 mai 2014
21 avr. 2014
publication
The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa
Lire plus06 mars 2014
04 mars 2014
publication
ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics
Lire plus12 févr. 2014
publication
A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread
Lire plus12 déc. 2013
publication
A Shigella effector dampens inflammation by regulating epithelial release of danger signal ATP through production of the lipid mediator PtdIns5P
Lire plus22 nov. 2013
publication
Rapid diagnosis of diarrhea caused by Shigella sonnei using dipsticks; comparison of rectal swabs, direct stool and stool culture
Lire plus01 nov. 2013
publication
The synergies of microorganisms enlightened – convergent approaches to delineating coinfections
Lire plus24 oct. 2013
22 juil. 2013
publication
Virulent Shigella flexneri affects secretion, expression, and glycosylation of gel-forming mucins in mucus-producing cells
Lire plus12 juin 2013
publication
Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.
Lire plus30 avr. 2013
publication
Epithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve
Lire plus01 avr. 2013
publication
A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes
Lire plus15 févr. 2013
01 janv. 2013
01 janv. 2013
10 déc. 2012
01 déc. 2012
13 sept. 2012
publication
Shigella effector IpaB-induced cholesterol relocation disrupts the Golgi complex and recycling network to inhibit host cell secretion
Lire plus24 août 2012
publication
The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak
Lire plus06 août 2012
publication
Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers
Lire plus04 juin 2012
publication
Quantitative RT-PCR profiling of the rabbit immune response: assessment of acute Shigella flexneri infection
Lire plus22 mai 2012
18 mai 2012
publication
Development of an efficient in vivo system (Pjunc-TpaseIS1223) for random transposon mutagenesis of Lactobacillus casei
Lire plus23 avr. 2012
publication
Hierarchies of host factor dynamics at the entry site of Shigella flexneri during host cell invasion
Lire plus16 mars 2012
publication
Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain
Lire plus15 mars 2012
publication
Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium’s epithelial niche
Lire plus12 mars 2012
publication
Characterization of the promoter, MxiE box and 5′ UTR of genes controlled by the activity of the type III secretion apparatus in Shigella flexneri
Lire plus01 mars 2012
01 janv. 2012
03 oct. 2011
publication
Dipstick test for rapid diagnosis of Shigella dysenteriae 1 in bacterial cultures and its potential use on stool samples
Lire plus20 sept. 2011
publication
Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling
Lire plus03 août 2011
publication
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Lire plus16 juin 2011
publication
ATP-mediated Erk1/2 activation stimulates bacterial capture by filopodia, which precedes Shigella invasion of epithelial cells
Lire plus24 mai 2011
publication
PCR-based identification of Klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma
Lire plus21 avr. 2011
publication
The Shigella flexneri type three secretion system effector IpgD inhibits T cell migration by manipulating host phosphoinositide metabolism.
Lire plus28 févr. 2011
01 févr. 2011
19 déc. 2010
publication
Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract
Lire plus07 déc. 2010
publication
Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione
Lire plus30 oct. 2010
publication
Safety, dose, immunogenicity, and transmissibility of an oral live attenuated Shigella flexneri 2a vaccine candidate (SC602) among healthy adults and school children in Matlab, Bangladesh
Lire plus01 août 2010
02 mai 2010
11 janv. 2010
publication
Tracking the dynamic interplay between bacterial and host factors during pathogen-induced vacuole rupture in real time
Lire plus21 déc. 2009
publication
Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control
Lire plus27 nov. 2009
14 oct. 2009
publication
Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits
Lire plus20 août 2009
publication
Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy
Lire plus01 août 2009
01 juil. 2009
publication
Framing a concept and an agenda for infectious diseases in EMBO Molecular Medicine
Lire plus01 mai 2009
01 avr. 2009
publication
WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics.
Lire plus05 mars 2009
publication
Characterisation of early mucosal and neuronal lesions following Shigella flexneri infection in human colon
Lire plus19 févr. 2009
15 févr. 2009
publication
A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection
Lire plus23 janv. 2009
publication
The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells
Lire plus09 janv. 2009
publication
Safety and immunogenicity of SC599, an oral live attenuated Shigella dysenteriae type-1 vaccine in healthy volunteers: results of a Phase 2, randomized, double-blind placebo-controlled trial
Lire plus01 déc. 2008
publication
Rhinoscleroma: a French national retrospective study of epidemiological and clinical features
Lire plus09 nov. 2008
publication
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases
Lire plus10 oct. 2008
publication
[“Neglected diseases”: it is better to respond to future challenges–the model of a pilot North-South program on enteric infections integrating many research components]
Lire plus10 juil. 2008
publication
Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?
Lire plus01 juil. 2008
12 juin 2008
publication
Commensals, bacterial pathogens and intestinal inflammation: an intriguing ménage à trois
Lire plus21 avr. 2008
publication
Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression
Lire plus01 avr. 2008
publication
War and peace at the intestinal epithelial surface: an integrated view of bacterial commensalism versus bacterial pathogenicity
Lire plus01 avr. 2008
publication
Maturation of paneth cells induces the refractory state of newborn mice to Shigella infection
Lire plus15 mars 2008
publication
Delivery of biologically active anti-inflammatory cytokines IL-10 and IL-1ra in vivo by the Shigella type III secretion apparatus
Lire plus15 févr. 2008
publication
SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases
Lire plus28 janv. 2008
11 janv. 2008
publication
Extracellular-loop peptide antibodies reveal a predominant hemichannel organization of connexins in polarized intestinal cells
Lire plus10 janv. 2008
publication
Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella
Lire plus08 déc. 2007
publication
IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri
Lire plus03 déc. 2007
publication
Phase 1 clinical trial of live attenuated Shigella dysenteriae type-1 DeltaicsA Deltaent Deltafep DeltastxA:HgR oral vaccine SC599 in healthy human adult volunteers
Lire plus12 nov. 2007
publication
Molecular and cellular bases of bacterial virulence: guessing the future episodes of an ongoing saga
Lire plus05 nov. 2007
publication
Roundtrip explorations of bacterial infection: from single cells to the entire host and back
Lire plus26 oct. 2007
publication
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction
Lire plus14 juin 2007
publication
Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy
Lire plus18 avr. 2007
01 avr. 2007
15 mars 2007
01 mars 2007
publication
[Shigella flexneri modulates host cell epigenetic information as a strategy to shape the transcriptional response]
Lire plus15 févr. 2007
publication
New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies
Lire plus02 févr. 2007
publication
Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain
Lire plus01 févr. 2007
09 janv. 2007
publication
Shigella’s ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?
Lire plus11 déc. 2006
10 déc. 2006
publication
An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses
Lire plus01 déc. 2006
24 oct. 2006
publication
Transcriptional slippage controls production of type III secretion apparatus components in Shigella flexneri
Lire plus18 oct. 2006
publication
IpaD is localized at the tip of the Shigella flexneri type III secretion apparatus
Lire plus01 sept. 2006
01 août 2006
01 mars 2006
publication
Rupture, invasion and inflammatory destruction of the intestinal barrier by Shigella: the yin and yang of innate immunity
Lire plus01 mars 2006
16 févr. 2006
publication
PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection
Lire plus01 févr. 2006
publication
Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine
Lire plus15 janv. 2006
publication
Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells
Lire plus01 janv. 2006
publication
Specific host genes required for the killing of Klebsiella bacteria by phagocytes
Lire plus01 janv. 2006
01 déc. 2005
publication
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
Lire plus18 nov. 2005
19 sept. 2005
publication
Identification of the critical residues involved in peptidoglycan detection by Nod1
Lire plus14 sept. 2005
publication
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes
Lire plus22 août 2005
publication
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
Lire plus01 août 2005
01 août 2005
publication
Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells
Lire plus01 juin 2005
publication
A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri
Lire plus31 mai 2005
publication
Mucosal lymphoid infiltrate dominates colonic pathological changes in murine experimental shigellosis
Lire plus01 avr. 2005
publication
Frameshifting by transcriptional slippage is involved in production of MxiE, the transcription activator regulated by the activity of the type III secretion apparatus in Shigella flexneri
Lire plus25 févr. 2005
01 févr. 2005
publication
Tyrosine kinase signaling and type III effectors orchestrating Shigella invasion
Lire plus01 janv. 2005
publication
Adherence modifies the regulation of gene expression induced by interleukin-10
Lire plus01 déc. 2004
17 oct. 2004
publication
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Lire plus15 sept. 2004
publication
IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis
Lire plus19 juil. 2004
publication
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells
Lire plus01 juin 2004
01 mai 2004
publication
Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo
Lire plus01 avr. 2004
01 avr. 2004
01 févr. 2004
01 déc. 2003
publication
Lessons from Nod2 studies: towards a link between Crohn’s disease and bacterial sensing
Lire plus01 août 2003
publication
Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells
Lire plus18 juil. 2003
01 juil. 2003
17 juin 2003
publication
The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco-2
Lire plus01 juin 2003
publication
Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells
Lire plus01 avr. 2003
publication
Shigella interaction with intestinal epithelial cells determines the innate immune response in shigellosis
Lire plus07 mars 2003
publication
Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases
Lire plus13 janv. 2003
publication
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
Lire plus01 déc. 2002
publication
Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri
Lire plus01 oct. 2002
publication
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology
Lire plus01 sept. 2002
publication
Epithelial inflammation response induced by Shigella flexneri depends on mucin gene expression
Lire plus01 sept. 2002
publication
Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction
Lire plus01 juil. 2002
publication
Human monocytes kill Shigella flexneri but then die by apoptosis associated with suppression of proinflammatory cytokine production
Lire plus01 juil. 2002
publication
Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo
Lire plus01 juin 2002
publication
The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model
Lire plus01 juin 2002
publication
Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2
Lire plus15 mai 2002
publication
Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium
Lire plus01 mai 2002
publication
Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells
Lire plus01 mai 2002
01 avr. 2002
publication
Intracellular vs extracellular recognition of pathogens–common concepts in mammals and flies
Lire plus01 mars 2002
publication
Regulation of transcription by the activity of the Shigella flexneri type III secretion apparatus
Lire plus01 mars 2002
publication
Spa15 of Shigella flexneri, a third type of chaperone in the type III secretion pathway
Lire plus30 janv. 2002
publication
The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells
Lire plus01 juil. 2000
publication
The interplay between receptor capping and cytoskeleton remodeling in Entamoeba histolytica
Lire plus01 mai 2000
publication
Cell polarization and adhesion in a motile pathogenic protozoan: role and fate of the Entamoeba histolytica Gal/GalNAc lectin
Lire plus01 juil. 1999
01 avr. 1999
publication
Myosin IB from Entamoeba histolytica is involved in phagocytosis of human erythrocytes
Lire plus01 juin 1998
publication
The small GTP-binding protein RacG regulates uroid formation in the protozoan parasite Entamoeba histolytica
Lire plus01 juin 1998
publication
Virulence and functions of myosin II are inhibited by overexpression of light meromyosin in Entamoeba histolytica
Lire plus01 oct. 1997
publication
Interaction between Entamoeba histolytica and intestinal epithelial cells involves a CD44 cross-reactive protein expressed on the parasite surface
Lire plus01 mai 1997
publication
Molecular characterization of myosin IB from the lower eukaryote Entamoeba histolytica, a human parasite
Lire plus01 janv. 1997
01 janv. 1997
publication
Rac G, a small GTPase, regulates capping of surface receptors in Entamoeba histolytica
Lire plus01 déc. 1996
publication
Identification and cellular localization of the actin-binding protein ABP-120 from Entamoeba histolytica
Lire plus01 nov. 1995
publication
Myosin II is involved in capping and uroid formation in the human pathogen Entamoeba histolytica
Lire plus01 mai 1993
publication
Identification and characterization of a myosin heavy chain gene (mhcA) from the human parasitic pathogen Entamoeba histolytica
Lire plus01 mars 1993
publication
Localization of myosin heavy chain A in the human pathogen Entamoeba histolytica
Lire plus01 janv. 1992