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© Research
Publication : Cell host & microbe

Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell host & microbe - 15 Jan 2015

Lhocine N, Arena ET, Bomme P, Ubelmann F, Prévost MC, Robine S, Sansonetti PJ

Link to Pubmed [PMID] – 25600187

Cell Host Microbe 2015 Feb;17(2):164-77

Salmonella invasion of intestinal epithelial cells requires extensive, though transient, actin modifications at the site of bacterial entry. The actin-modifying protein villin is present in the brush border where it participates in the constitution of microvilli and in epithelial restitution after damage through its actin-severing activity. We investigated a possible role for villin in Salmonella invasion. The absence of villin, which is normally located at the bacterial entry site, leads to a decrease in Salmonella invasion. Villin is necessary for early membrane-associated processes and for optimal ruffle assembly by balancing the steady-state level of actin. The severing activity of villin is important for Salmonella invasion in vivo. The bacterial phosphatase SptP tightly regulates villin phosphorylation, while the actin-binding effector SipA protects F-actin and counterbalances villin-severing activity. Thus, villin plays an important role in establishing the balance between actin polymerization and actin severing to facilitate the initial steps of Salmonella entry.

http://www.ncbi.nlm.nih.gov/pubmed/25600187