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© Research
Publication : Annals of the New York Academy of Sciences

The bacterial weaponry: lessons from Shigella

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annals of the New York Academy of Sciences - 01 Aug 2006

Sansonetti PJ

Link to Pubmed [PMID] – 17057210

Ann. N. Y. Acad. Sci. 2006 Aug;1072:307-12

Shigella, a Gram-negative bacterial species of the family Enterobacteriaceae, causes bacillary dysentery in humans, an acute rectocolitis that reflects the capacity of the microorganism to disrupt, invade, and cause the inflammatory destruction of the intestinal epithelium. Here, the pathogenesis of Shigella infection is analyzed in the context of the disruption of the homeostatic balance that protects the gut against inflammation in the presence of its commensal flora. Thus a unified view by which enteroinvasive pathogens allow identification of key signalling molecules and pathways involved in the regulation of intestinal inflammation, thereby providing keys to understand inflammatory bowel diseases (IBDs) such as Crohn’s disease and ulcerative colitis.

http://www.ncbi.nlm.nih.gov/pubmed/17057210