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© Research
Publication : Nature reviews. Microbiology

Life on the inside: the intracellular lifestyle of cytosolic bacteria

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Microbiology - 01 May 2009

Ray K, Marteyn B, Sansonetti PJ, Tang CM

Link to Pubmed [PMID] – 19369949

Nat. Rev. Microbiol. 2009 May;7(5):333-40

Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can invade non-phagocytic cells and survive within a membrane-bound compartment. However, only a small number of bacteria, including Listeria monocytogenes, Shigella flexneri, Burkholderia pseudomallei, Francisella tularensis and Rickettsia spp., can gain access to and proliferate within the host cell cytosol. Here, we discuss the mechanisms by which these cytosolic pathogens escape into the cytosol, obtain nutrients to replicate and subvert host immune responses.

http://www.ncbi.nlm.nih.gov/pubmed/19369949