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© Research
Publication : The Journal of infectious diseases

Mucosal lymphoid infiltrate dominates colonic pathological changes in murine experimental shigellosis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 31 May 2005

Martino MC, Rossi G, Martini I, Tattoli I, Chiavolini D, Phalipon A, Sansonetti PJ, Bernardini ML

Link to Pubmed [PMID] – 15942903

J. Infect. Dis. 2005 Jul;192(1):136-48

Shigella species are invasive human pathogens that cause acute rectocolitis by triggering a dysregulated inflammatory reaction in the colonic and rectal mucosa. Because mice are naturally resistant to shigellosis, there is no mouse model that mimics human disease. We explore the susceptibility of intestinal flora-depleted mice to shigellosis after intragastric infection with Shigella strains.