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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
01
Mar 2017
Status
Not started
Members
4
Structures
3
Instituts
1

About

Undernutrition contributes to more than 40% of the global child mortality rate. In 2014 stunting, which is the main manifestation of chronic undernutrition, affected 159 million children. Stunting entails long-term repercussions for the child, such as impaired growth, defective immune response, and neuro-cognitive consequences. Epidemiologic studies emphasize that undernutrition cannot be ascribed solely to food insecurity and that early life environmental exposures play a major role in the pathogenesis of the disease. Indeed, growing evidence indicates that a syndrome called pediatric environmental enteropathy (PEE) undermines the physiological nutrition process. PEE is a chronic low-grade inflammation of the small intestine in response to repeated exposure to a highly microbiologically contaminated environment. This entails changes in the resident gut microbiota and intestinal atrophy, eventually leading to nutrient malabsorption, and deficient responses to live-oral vaccines. Estimates indicate that up to 75-100% of children living in the most impoverished areas with high prevalence of enteric infections suffer from PEE. Identifying how the infant acquires a pediatric environmental enteropathy and a dysbiotic gut microbiota are the crucial questions to elucidate the pathological pathways associated with malnutrition and design future intervention strategies.

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