Speakers
Olivier BAUD, MD-PhD
(Service de Médecine et Réanimation Néonatales de Port-Royal Hôpital Universitaire Cochin, Université de Genève, Département de Pédiatrie, Gynécologie et Obstétrique)
Date
25
Jun 2025
Time
12:00:00
Address
Room: Auditorium F. Jacob
Location
2025-06-25 12:00:00
2025-06-25 13:00:00
Europe/Paris
“Mother & Child Health” Seminar: Perinatal inflammation and prematurity : from prenatal causes to postnatal consequences
Globally, 13.4 million babies are born prematurely each year; postnatal complications associated with preterm birth are one of the leading causes of death in children under 5 worldwide. While the mortality of most preterm […]
Philippe Sansonetti
philippe.sansonetti@pasteur.fr
About
Globally, 13.4 million babies are born prematurely each year; postnatal complications associated with preterm birth are one of the leading causes of death in children under 5 worldwide. While the mortality of most preterm infants is decreasing, the incidence of postnatal adverse events either remains stable or has recently increased, leading to long-term negative effects on growth, neurodevelopment and lung function. Many factors can lead to spontaneous or medically indicated preterm birth, with the maternal/fetal inflammatory process being the main trigger for preterm birth. After birth, very preterm neonates are also exposed to persistent systemic inflammation related to their endogenous immaturity, and repeated environmental inflammatory hits triggered by hemodynamic failure, exacerbated oxidative stress, and postnatal infections. There is growing evidence that perinatal inflammation is a major cause of preterm birth, a common feature of short-term neonatal complications and a risk factor for long-term morbidity that needs lifelong medical support. This talk will summarize epidemiological aspects related to prematurity and the causal link between perinatal inflammation, parturition, postnatal complications and long-term consequences of prematurity.
Interested scientists who would like to discuss with the speaker can contact Hafida.fsihi@pasteur.fr to arrange a meeting.