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© Research
Publication : Current opinion in microbiology

Sensing of bacteria: NOD a lonely job

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 11 Dec 2006

Kufer TA, Sansonetti PJ

Link to Pubmed [PMID] – 17161646

Curr. Opin. Microbiol. 2007 Feb;10(1):62-9

Recognition of bacteria by the vertebrate innate immune system relies on detection of invariant molecules by specialized receptors. The view is emerging that activation of both Toll-like receptors (TLRs) and Nod-like receptors (NLRs) by different bacterial agonists is important in order to mount an inflammatory response in the host. Priming of cells with peptidoglycan and products that are sensed by cytosolic-localized members of the NLR family have a synergistic effect on TLR signalling and vice versa. Currently, the underlying molecular mechanisms of this cross-talk between NLR and TLR signalling are beginning to emerge. These reveal that the two sensing-systems are non-redundant in bacterial recognition and that their cross-talk plays an important role in immunological homeostasis.

http://www.ncbi.nlm.nih.gov/pubmed/17161646