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© Research
Publication : Cell host & microbe

Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell host & microbe - 14 Jun 2007

Arbibe L, Sansonetti PJ

Link to Pubmed [PMID] – 18005703

Cell Host Microbe 2007 Jun;1(4):244-6

Tolerance to lipopolysaccharide (LPS) is part of the host’s strategy to avoid harmful excessive inflammation in the presence of Gram-negative commensals and pathogens. Macrophages are the major cells endowed with this property, allowing them to limit expression of proinflammatory genes while maintaining efficient antimicrobial functions. In a recent paper, Foster et al. (2007) demonstrate that this subtle balance is established and imprinted via epigenetic regulation.

http://www.ncbi.nlm.nih.gov/pubmed/18005703