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© Research
Publication : Immunity

Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells

Team: Biological Image Analysis
Team: Group : Régis Tournebize
Member: Jean-Christophe Olivo-Marin
Member: Philippe Sansonetti
Member: Armelle Phalipon
Member: Régis Tournebize
Member: Thierry Pedron
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunity - 01 Jun 2003

Fernandez MI, Pedron T, Tournebize R, Olivo-Marin JC, Sansonetti PJ, Phalipon A

Link to Pubmed [PMID] – 12818156

Immunity 2003 Jun;18(6):739-49

Intestinal epithelial cells (IEC) play a central role in innate and acquired mucosal immunity. They ensure early signaling to trigger an inflammatory response against pathogens. Moreover, IEC mediate transcytosis of dimeric IgA (dIgA), through the polymeric-immunoglobulin receptor (pIgR), to provide secretory IgA, the major protective Ig in mucosal secretions. Using an in vitro model of polarized IEC, we describe an additional anti-inflammatory mechanism of dIgA-mediated protection against intracellular bacterial components involved in the proinflammatory activation of IEC. Specific dIgA colocalizes to lipopolysaccharide (LPS) in the apical recycling endosome compartment, preventing LPS-induced NF-kappaB translocation and subsequent proinflammatory response. Thus, intracellular neutralization by dIgA limits the acute local inflammation induced by proinflammatory pathogen-associated molecular patterns such as LPS.