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© Research
Publication : Molecular microbiology

SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular microbiology - 15 Feb 2008

Mazurkiewicz P, Thomas J, Thompson JA, Liu M, Arbibe L, Sansonetti P, Holden DW

Link to Pubmed [PMID] – 18284579

Mol. Microbiol. 2008 Mar;67(6):1371-83

SpvC is encoded by the Salmonella virulence plasmid. We have investigated the biochemical function of SpvC and the mechanism by which it is secreted by bacteria and translocated into infected macrophages. We constructed a strain carrying a deletion in spvC and showed that the strain is attenuated for systemic virulence in mice. SpvC can be secreted in vitro by either the SPI-1 or SPI-2 type III secretion systems. Cell biological and genetic experiments showed that translocation of the protein into the cytosol of macrophages by intracellular bacteria is dependent on the SPI-2 T3SS. Using antibodies specific to phospho-amino acids and mass spectrometry we demonstrate that SpvC has phosphothreonine lyase activity on full-length phospho-Erk (pErk) and a synthetic 13-amino-acid phospho-peptide containing the TXY motif. A Salmonella strain expressing spvC from a plasmid downregulated cytokine release from infected cells.

http://www.ncbi.nlm.nih.gov/pubmed/18284579