Timeline
Christophe D’Enfert
Head of Structure
05 Dec 2024
publication
β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall.
Read more01 Jun 2024
publication
Metabolic reprogramming during Candida albicans planktonic-biofilm transition is modulated by the transcription factors Zcf15 and Zcf26.
Read more11 Apr 2024
publication
A gain-of-function mutation in zinc cluster transcription factor Rob1 Drives Candida albicans adaptive growth in the cystic fibrosis lung environment.
Read more01 Dec 2023
publication
Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response.
Read more19 Sep 2023
17 May 2023
25 Jan 2023
publication
The Pga59 cell wall protein is an amyloid forming protein involved in adhesion and biofilm establishment in the pathogenic yeast Candida albicans.
Read more12 Sep 2022
publication
Bending stiffness of Candida albicans hyphae as a proxy of cell wall properties.
Read more23 Jul 2022
publication
A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans.
Read more19 Jul 2022
publication
Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.
Read more01 Jul 2022
publication
A protocol for ultrastructural study of Candida albicans biofilm using transmission electron microscopy.
Read more21 Jun 2022
publication
Multiple Stochastic Parameters Influence Genome Dynamics in a Heterozygous Diploid Eukaryotic Model.
Read more01 Jan 2022
publication
Functional Portrait of Irf1 (Orf19.217), a Regulator of Morphogenesis and Iron Homeostasis in Candida albicans.
Read more26 Aug 2021
01 Apr 2021
publication
Regulators of commensal and pathogenic life-styles of an opportunistic fungus-Candida albicans.
Read more27 Mar 2021
18 Mar 2021
10 Mar 2021
publication
Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans.
Read more27 Jan 2021
publication
Involvement of amyloid proteins in the formation of biofilms in the pathogenic yeast Candida albicans.
Read more04 Dec 2020
publication
A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans.
Read more24 Nov 2020
publication
The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.
Read more02 Sep 2020
publication
Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in Candida albicans.
Read more01 Jul 2020
publication
Candida albicans and Candida dubliniensis Show Different Trailing Effect Patterns When Exposed to Echinocandins and Azoles.
Read more01 Apr 2020
publication
Large-scale genome mining allows identification of neutral polymorphisms and novel resistance mutations in genes involved in Candida albicans resistance to azoles and echinocandins.
Read more01 Apr 2020
31 Jan 2020
01 Jan 2020
publication
Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans.
Read more09 Aug 2019
publication
The Candida albicans biofilm gene circuit modulated at the chromatin level by a recent molecular histone innovation
Read more29 Jul 2019
event
Candida albicans invasion into epithelial layers: Integrating dynamics, structure and function at the pathogen-host interface- Allon Weiner
Read more04 Jun 2019
25 Apr 2019
publication
Studying fungal pathogens of humans and fungal infections: fungal diversity and diversity of approaches
Read more25 Apr 2019
15 Mar 2019
event
Genetic and Epigenetic Mechanisms Driving Phenotypic Diversity in Pathogenic Candida Species – Richard Bennett
Read more14 Mar 2019
28 Feb 2019
publication
Candida albicans: An Emerging Yeast Model to Study Eukaryotic Genome Plasticity
Read more22 Feb 2019
13 Feb 2019
publication
Identification of Recessive Lethal Alleles in the Diploid Genome of a Candida albicans Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact
Read more07 Jan 2019
event
Mini-symposium: Kick-off meeting of the FunHoMic Marie Curie Innovative Training Network – Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections
Read more07 Jan 2019
project
FunHoMic MC-ITN: Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections
Read more01 Jan 2019
publication
From Genes to Networks: The Regulatory Circuitry Controlling Candida albicans Morphogenesis.
Read more14 Dec 2018
event
“Understanding antifungal drug resistance and tolerance in fungal pathogens : impact of genomics” Dominique Sanglard
Read more02 Nov 2018
01 Nov 2018
publication
Systematic gene overexpression in Candida albicans identifies a regulator of early adaptation to the mammalian gut.
Read more07 Sep 2018
event
Phd Thesis defense “La Candidose cutanéo-muqueuse chronique : un modèle d’étude de l’adaptation génomique chez C.albicans “
Read more22 Aug 2018
21 Aug 2018
03 Aug 2018
publication
Combined bacterial and fungal intestinal microbiota analyses: Impact of storage conditions and DNA extraction protocols
Read more03 Jul 2018
14 Jun 2018
publication
Methodologies for and evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms
Read more08 Jun 2018
publication
Gene flow contributes to diversification of the major fungal pathogen Candida albicans
Read more07 Feb 2018
event
“Candida albicans centromere biology” by Kaustuv SANYAL – Mycology Department Seminar
Read more20 Nov 2017
publication
Azole resistance in a mutant lacking the ABC transporter depends on TOR signaling
Read more16 Nov 2017
28 Jul 2017
publication
The two-component response regulator Skn7 belongs to a network of transcription factors regulating morphogenesis in Candida albicans and independently limits morphogenesis-induced ROS accumulation.
Read more18 May 2017
08 Feb 2017
publication
The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity
Read more11 Oct 2016
publication
Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome
Read more11 Jul 2016
publication
Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin.
Read more16 Jun 2016
publication
Prospective Evaluation of Serum β-Glucan Testing in Patients With Probable or Proven Fungal Diseases
Read more29 Mar 2016
publication
Mechanisms Underlying the Delayed Activation of the Cap1 Transcription Factor in Candida albicans following Combinatorial Oxidative and Cationic Stress Important for Phagocytic Potency.
Read more29 Mar 2016
publication
Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence
Read more05 Feb 2016
publication
Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades
Read more16 Dec 2015
publication
Biofilm formation in Candida glabrata: What have we learnt from functional genomics approaches?
Read more06 Sep 2015
02 Sep 2015
02 Sep 2015
02 Sep 2015
01 Sep 2015
01 Sep 2015
04 Aug 2015
publication
Candida albicans is able to use M cells as a portal of entry across the intestinal barrier in vitro
Read more11 May 2015
15 Apr 2015
publication
A single nucleotide polymorphism uncovers a novel function for the transcription factor Ace2 during Candida albicans hyphal development
Read more18 Mar 2015
18 Mar 2015
publication
Of mice, flies–and men? Comparing fungal infection models for large-scale screening efforts
Read more16 Jan 2015
publication
A FACS-optimized screen identifies regulators of genome stability in Candida albicans
Read more04 Dec 2014
publication
Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant
Read more30 Oct 2014
publication
One small step for a yeast–microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation
Read more08 Oct 2014
publication
Name changes in medically important fungi and their implications for clinical practice
Read more24 Aug 2014
publication
Genetic diversity among Candida albicans isolates associated with vertical transmission in preterm triplets
Read more01 Aug 2014
publication
Multilocus sequence typing for the analysis of clonality among Candida albicans strains from a neonatal intensive care unit
Read more19 Jun 2014
publication
Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes
Read more25 Dec 2013
publication
A study of the DNA damage checkpoint in Candida albicans: uncoupling of the functions of Rad53 in DNA repair, cell cycle regulation and genotoxic stress-induced polarized growth
Read more05 Dec 2013
publication
Rbt1 protein domains analysis in Candida albicans brings insights into hyphal surface modifications and Rbt1 potential role during adhesion and biofilm formation
Read more11 Sep 2013
15 Aug 2013
publication
A comprehensive functional portrait of two heat shock factor-type transcriptional regulators involved in Candida albicans morphogenesis and virulence.
Read more31 Jul 2013
publication
Candida albicans is not always the preferential yeast colonizing humans: a study in Wayampi Amerindians
Read more30 Apr 2013
publication
Antifungal activity of fused Mannich ketones triggers an oxidative stress response and is Cap1-dependent in Candida albicans
Read more06 Apr 2013
publication
Candida albicans biofilms: building a heterogeneous, drug-tolerant environment
Read more18 Mar 2013
publication
SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis
Read more01 Feb 2013
publication
Synergy of the antibiotic colistin with echinocandin antifungals in Candida species
Read more18 Jan 2013
publication
A novel bioluminescence mouse model for monitoring oropharyngeal candidiasis in mice
Read more17 Aug 2012
publication
Using a Multi-Locus Microsatellite Typing method improved phylogenetic distribution of Candida albicans isolates but failed to demonstrate association of some genotype with the commensal or clinical origin of the isolates
Read more10 May 2012
publication
The NDR/LATS kinase Cbk1 controls the activity of the transcriptional regulator Bcr1 during biofilm formation in Candida albicans
Read more03 Mar 2012
01 Jan 2012
publication
A luciferase reporter for gene expression studies and dynamic imaging of superficial Candida albicans infections.
Read more01 Jan 2012
01 Jan 2012
01 Jan 2012
01 Aug 2011
publication
Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans
Read more27 Jul 2011
11 May 2011
publication
Genetic diversity among Korean Candida albicans bloodstream isolates: assessment by multilocus sequence typing and restriction endonuclease analysis of genomic DNA by use of BssHII
Read more06 Apr 2011
publication
Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans
Read more10 Feb 2011
01 May 2010
01 Mar 2010
publication
Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans
Read more22 Jan 2010
publication
The transposon impala is activated by low temperatures: use of a controlled transposition system to identify genes critical for viability of Aspergillus fumigatus
Read more25 Dec 2009
publication
A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique
Read more18 Dec 2009
publication
Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model
Read more14 Dec 2009
publication
Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy
Read more01 Sep 2009
17 Aug 2009
publication
A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections
Read more21 Jun 2009
publication
Hidden killers: persistence of opportunistic fungal pathogens in the human host
Read more21 Apr 2009
publication
The GPI-modified proteins Pga59 and Pga62 of Candida albicans are required for cell wall integrity
Read more31 Mar 2009
publication
Candida albicans internalization by host cells is mediated by a clathrin-dependent mechanism
Read more16 Jan 2009
publication
Correlation between biofilm formation and the hypoxic response in Candida parapsilosis
Read more21 Dec 2008
publication
Loss of heterozygosity in commensal isolates of the asexual diploid yeast Candida albicans
Read more17 Jun 2008
05 Dec 2007
publication
Multilocus sequence typing reveals that the population structure of Candida dubliniensis is significantly less divergent than that of Candida albicans
Read more01 Dec 2007
publication
The SUN41 and SUN42 genes are essential for cell separation in Candida albicans
Read more26 Nov 2007
publication
CandidaDB: a multi-genome database for Candida species and related Saccharomycotina
Read more23 Oct 2007
publication
Mating is rare within as well as between clades of the human pathogen Candida albicans
Read more02 Oct 2007
publication
Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome
Read more10 Aug 2007
publication
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates
Read more06 Apr 2007
28 Jan 2007
publication
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Read more01 Oct 2006
publication
Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans
Read more01 May 2006
publication
Multilocus sequence typing reveals intrafamilial transmission and microevolutions of Candida albicans isolates from the human digestive tract
Read more01 Apr 2006
publication
Biofilms and their role in the resistance of pathogenic Candida to antifungal agents
Read more20 Mar 2006
22 Dec 2005
publication
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
Read more01 Aug 2005
publication
Phosphatidylinositol-dependent phospholipases C Plc2 and Plc3 of Candida albicans are dispensable for morphogenesis and host-pathogen interaction
Read more17 Jun 2005
08 Jun 2005
publication
The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans
Read more01 Feb 2005
publication
The Yak1p kinase controls expression of adhesins and biofilm formation in Candida glabrata in a Sir4p-dependent pathway
Read more01 Jan 2005
01 Sep 2004
publication
Multilocus sequence typing of Candida albicans: strategies, data exchange and applications
Read more01 Apr 2004
publication
Candida albicans biofilms: a developmental state associated with specific and stable gene expression patterns
Read more01 Nov 2003
publication
Collaborative consensus for optimized multilocus sequence typing of Candida albicans
Read more01 Jul 2003
publication
Glycerol dehydrogenase, encoded by gldB is essential for osmotolerance in Aspergillus nidulans
Read more01 Apr 2003
publication
Identification of essential genes in the human fungal pathogen Aspergillus fumigatus by transposon mutagenesis
Read more01 Mar 2003
01 Oct 2002
01 Jul 2002
publication
Characterization of essential genes by parasexual genetics in the human fungal pathogen Aspergillus fumigatus: impact of genomic rearrangements associated with electroporation of DNA
Read more01 May 2002
publication
cAMP and ras signalling independently control spore germination in the filamentous fungus Aspergillus nidulans
Read more01 Apr 2002
publication
Usefulness of multilocus sequence typing for characterization of clinical isolates of Candida albicans
Read more01 Nov 2001
publication
Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1
Read more01 Sep 2001
publication
NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans
Read more01 Jul 2001
publication