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© Research
Publication : Research in microbiology

Involvement of amyloid proteins in the formation of biofilms in the pathogenic yeast Candida albicans.

Team: Fungal Biology and Pathogenicity
Member: Christophe D’Enfert
Member: Thierry Mourer
Member: Sophie Bachellier-Bassi
Member: Olivier Cordin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Research in microbiology - 27 Jan 2021

Mourer T, El Ghalid M, d'Enfert C, Bachellier-Bassi S,

Link to Pubmed [PMID] – 33515679

Link to DOI – S0923-2508(21)00026-710.1016/j.resmic.2021.103813

Res Microbiol 2021 Jan; (): 103813

Candida species represent a major fungal threat for human health. Within the Candida genus, the yeast Candida albicans is the most frequently incriminated species during episodes of candidiasis or candidemia. Biofilm formation is used by C. albicans to produce a microbial community that is important in an infectious context. The cell wall, the most superficial cellular compartment, is of paramount importance regarding the establishment of biofilms. C. albicans cell wall contains proteins with amyloid properties that are necessary for biofilm formation due to their adhesion properties. This review focuses on these amyloid proteins during biofilm formation in the yeast C. albicans.