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  • Associate Professor
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  • PhD Student
  • Physician
  • Post-doc
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  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
02
Sep 2015
Status
Ongoing
Members
8
Structures
2
Publications
19

About

Following our introduction of Multi-Locus Sequence Typing (MLST) as the state-of-the-art methodology for molecular epidemiology studies of C. albicans, the Fungal Biology and Pathogenicity Unit at Institut Pasteur is now progressing into population genomics studies of C. albicans. Knowledge gained by MLST and genome sequencing inform us on the mechanisms used to generate diversity within the C. albicanspopulation and paves the way to identifying the genetic determinants that underlie phenotypic diversity across C. albicans isolates. We have recently generated genome sequences for 150 C. albicans strains which we previously isolated from diverse sources.Our genomic analyses have confirmed a predominantly clonal mode of reproduction in the sampled C. albicans population and emphasized the importance of loss-of-heterozygosity (LOH) as a driver of genomic diversity among these isolates. LOH events also play important roles in the acquisition of antifungal resistance by C. albicans. We are investigating the molecular mechanisms that control LOH and have shown that the Rad53 and Dun1 protein kinases of the DNA damage checkpoint are required to maintain heterozygosity. Furthermore, we have established a novel fluorescence-based reporter system to facilitate the identification of C. albicans genes with previously unknown roles in the control of LOH events. Our ongoing research will continue to pursue the characterization of the molecular mechanisms controlling genome stability in C. albicans.Our access to genome sequences for phenotypically diverse C. albicans isolates will also allow us to develop genotype-to-phenotype association studies in this species.

Fundings

References