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© Vishu Aimanianda, Institut Pasteur
Cryptococcus neoformans with chitin (blue) and capsule (green) labelings
Event

Candida albicans invasion into epithelial layers: Integrating dynamics, structure and function at the pathogen-host interface- Allon Weiner

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
12
Sep 2019
Time
12:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: François Jacob Room: Auditorium François Jacob
Location
2019-09-12 12:00:00 2019-09-12 13:00:00 Europe/Paris Candida albicans invasion into epithelial layers: Integrating dynamics, structure and function at the pathogen-host interface- Allon Weiner Allon Weiner – Faculté de Médecine Sorbonne Université, Site Pitié-Salpêtrière – Cimi Paris Many pathogens possess the ability to invade host tissues using complex strategies that allow breaching of host barriers, subversion of host […] Institut Pasteur, Rue du Docteur Roux, Paris, France Christophe D’Enfert christophe.denfert@pasteur.fr

About

Allon Weiner – Faculté de Médecine Sorbonne Université, Site Pitié-Salpêtrière – Cimi Paris

Many pathogens possess the ability to invade host tissues using complex strategies that allow breaching of host barriers, subversion of host biological pathways and uptake of host resources. Invasion is often highly dynamic, occurs in remodeled cellular environments, and involves many pathogen and host molecular factors. Therefore, investigation of invasion requires combining high spatio-temporal resolution approaches with functional and molecular information obtained at the single cell level. In our recently opened ATIP-Avenir research group, we study invasion by the opportunistic fungal pathogen Candida albicans using live imaging, cutting edge correlative “volume” electron tomography and cell biology approaches. We aim to resolve the seemingly contradictory paradigm of C. albicans invasion as an intracellular process that causes no cellular damage, reveal the precise role of pathogen and host factors in regulation of invasion and establish a mechanistic understanding of this enigmatic process.

website: www.weinerlab.org

Location

Building: François Jacob
Room: Auditorium François Jacob
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France