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  • Associate Professor
  • Clinical Research Assistant
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  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
02
Sep 2015
Status
Ongoing
Members
6
Structures
2
Publications
10

About

The Fungal Biology and Pathogenicity Unit at Institut Pasteur is interested in the regulation of the yeast-to-hypha transition in C. albicans because of its role in biofilm formation and, more generally, in virulence. While yeast cells are able to colonize tissues and disseminate in the bloodstream, hypha formation contributes to escape from phagocytic cells and breach crossing of tissue barriers. Numerous cues, such as temperature, CO2, serum, have been described to regulate the yeast-to-hypha transition and an extensive knowledge has been gained from the signaling components that integrate these cues into the morphogenetic program. Yet, much remains to be understood of how extracellular cues are transduced and of the interplay between the different signaling pathway components.

Our study of the regulatory networks governing hyphal morphogenesis stems from several gain-of-function screens that have identified genes whose overexpression triggers pseudo-hyphal or hyphal morphogenesis independently of the occurrence of hypha-inducing cues. In particular, we have investigated the role of two heat-shock factor-like transcription factors, namely Sfl1 and Sfl2, and we have shown that they act as central “switch on/off” proteins that confer temperature-dependent regulation of morphogenesis.

Present research focuses on the characterization of additional transcription factors involved in C. albicans morphogenesis and their involvement in C. albicans stress responses.

Fundings

References