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© Vishu Aimanianda, Institut Pasteur
Cryptococcus neoformans with chitin (blue) and capsule (green) labelings
Event

Genetic and Epigenetic Mechanisms Driving Phenotypic Diversity in Pathogenic Candida Species – Richard Bennett

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
18
Apr 2019
Time
12:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: François Jacob
Location
2019-04-18 12:00:00 2019-04-18 13:00:00 Europe/Paris Genetic and Epigenetic Mechanisms Driving Phenotypic Diversity in Pathogenic Candida Species – Richard Bennett Richard Bennett –Molecular Microbiology and Immunology Department, Brown University, Providence, USA Candida albicans is a frequent commensal of the human body and an opportunistic pathogen of both mucosal and systemic niches.  Our laboratory looks […] Institut Pasteur, Rue du Docteur Roux, Paris, France Christophe D’Enfert christophe.denfert@pasteur.fr

About

Richard BennettMolecular Microbiology and Immunology Department, Brown University, Providence, USA

Candida albicans is a frequent commensal of the human body and an opportunistic pathogen of both mucosal and systemic niches.  Our laboratory looks at the mechanisms used by C. albicans to generate phenotypic diversity and to adapt to different niches in the host.  Genetic mechanisms that increase diversity include an unusual parasexual mating cycle in which a non-meiotic program of concerted chromosome loss reduces the ploidy of mating products.  We also examine epigenetic mechanisms such as those responsible for reversible ‘phenotypic switching’ between alternative fungal cell states.  Models of gastrointestinal tract colonization and disseminated disease are used to determine how genetic and epigenetic diversity in C. albicans impact infection outcomes.

Location

Building: François Jacob
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France