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© Research
Publication : Yeast (Chichester, England)

Regulators of commensal and pathogenic life-styles of an opportunistic fungus-Candida albicans.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Yeast (Chichester, England) - 01 Apr 2021

Rai LS, Wijlick LV, Bougnoux ME, Bachellier-Bassi S, d'Enfert C,

Link to Pubmed [PMID] – 33533498

Link to DOI – 10.1002/yea.3550

Yeast 2021 Apr; 38(4): 243-250

The yeast Candida albicans is primarily a commensal of humans that colonizes the mucosal surfaces of the gastrointestinal and genital tracts. Yet, C. albicans can under certain circumstances undergo a shift from commensalism to pathogenicity. This transition is governed by fungal factors such as morphological transitions, environmental cues for instance relationships with gut microbiota and the host immune system. C. albicans utilizes distinct sets of regulatory programs to colonize or infect its host and to evade the host defense systems. Moreover, an orchestrated iron acquisition mechanism operates to adapt to specific niches with variable iron availability. Studies on regulatory networks and morphogenesis of these two distinct modes of C. albicans growth, suggest that both yeast and hyphal forms exist in both growth patterns and the regulatory circuits are inter-connected. Here, we summarize current knowledge about C. albicans commensal-to-pathogen shift, its regulatory elements and their contribution to human disease.

https://pubmed.ncbi.nlm.nih.gov/33533498