The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to understand the underlying principles of complex biological behavior in terms of physical and mathematical models. This approach overarches all fields of biology.
Pathogenesis of vascular infections
Dynamics of Host-Pathogen Interactions
Imaging and Modeling
Dynamics of Developmental Decisions in Drosophila
Cell Polarity, Migration And Cancer
Human Evolutionary Genetics
Biological Image Analysis
Neural circuits for spatial navigation and memory
Membrane Traffic and Pathogenesis
Group: Translation dependent mRNA degradation
Spatial Regulation of Genomes
Basic hearing mechanisms and precision medicine
Biochemistry of Macromolecular Interactions
Stem Cells And Development
Bacterial Genome Plasticity
Dynamic Regulation of Morphogenesis
InBio: Experimental and Computational Methods for Modeling Cellular Processes
Synapse and Circuit Dynamics
Neural Circuit Dynamics and Decision Making
Physical Microfluidics and Bioengineering
Cell death and epithelial homeostasis
Physics of Biological Function
Decision and Bayesian Computation
Internship : Development of a user-friendly pipeline for Graph Neural Network (GNN) based biomolecule trajectories analysis
• October 17th 2016: “Kick off meeting” of the Qbio program (Guillaume Duménil, Sven van Teeffelen)
• June 9th 2017: “Forces in Biology” (Romain Levayer, Nicolas Dray, Sandrine Etienne-Manneville, Patrick England, Alexandre Dufour).
• May 25th 2018: “Physics of Biological Membranes” (Thomas Wollert (IP), Patricia Bassereau (Curie))
• October 11-12 2018: “Neural networks – from machines to brains” (David Di Gregorio, JB Masson, and Christoph Schmidt-Hieber (IP), Rémi Monasson (ENS))
• January 2019: “Quantitative cell biology of bacteria“ (Guillaume Duménil, Sven van Teeffelen)
Future symposia :
• June 2021: “Bridging the scales, from single cells, to populations, tissues and organs” (Charles Baroud, Romain Levayer)
If you wish to be informed by email please sign up on the Qbio@pasteur.fr mailing list. Connect to this address : https://email.pasteur.fr/ Go to the Settings menu then options and then groups and sign-in.
Quantitative biology at the Institut Pasteur
Many Pasteur laboratories are integrating physical approaches in their studies ranging from structural biology, via cell biology, to infection, neurobiology and development.
• Multiscale self-organization is studied at the level of protein machineries in bacteria, cytoskeleton during the migration of eucaryotic cells and organizaton of tissues during development.
• Cellular and tissue mechanics are explored during bacterial aggregation, grastrulation and heart development as well as during amoebae movement.
• Information processing and signaling are studied in the context of neurobiology, 3D genome architecture, transciption and cell decision making.
Objectives of the Qbio program at Institut Pasteur
The Quantitative Biology program aims to encourage these developments on campus. The major purpose of this program is:
• To foster interactions between scientists involved in Quantitative Biology at Institut Pasteur through seminars and mini-symposiums.
• To bring quantitatively trained scientists into biology
• To encourage biologists to integrate quantitative models into their research
Qbio progress reports
The Qbio programm organise monthly progress reports where early career scientists (PhD, postdoc) present ongoing projects at the interface between biology, physics and/or mathematics in an informal setting. The primary aim is to foster interactions on the campus. The meetings currently take place online on Thursdays at 2pm. Contact the organisers if you would like to join.
You will find the current programm below :
|March 11th||Presentation 1||Assessing single-bacteria response to antibiotics (Andrey Aristov + Lena Le Quellec, Baroud Lab)|
|Presentation 2||Modeling and efficient characterization of enzyme-mediated response to antibiotics (Virgile Andreani, InBio)|
|April 15th||Presentation 1||spatiotemporal dynamic of neural stem cell fate decisions (Nicolas Dray, Laure Bally-Cuif lab)|
|Presentation 2||Laure Leblanc, Labo Duménil, Bacterial growth under confinement|
|May 20th||Presentation 1||Operant learning and multi armed bandit game playing with drosophila larva (Chloe barre, labo DBC)|
|Presentation 2||From the embryonic heart loop to congenital heart defects (Audrey Desgrange, labo, SM)|
|June 17th||Presentation 1||Group David di Gregorio|
|Presentation 2||Role of intermediate filaments in the mechanics of invading cells (Emma van Bodegraven, Labo PCMC)|
|September 9th||Presentation 1||Interdisciplinary characterization of DNA repair in yeast cells (Nadia Vertti-Quintero, Baroud lab)|
|Presentation 2||Epithelial robustness is an emergening property of local ERK feedbacks driven by cell death (Léo Valon, group Romain Levayer)|
|October 14th||Presentation 1||Unsupervised learning of heterogenous random walks (Hippolyte Verdier, labo DBC)|
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