The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to understand the underlying principles of complex biological behavior in terms of physical and mathematical models. This approach overarches all fields of biology.
Coordination
Teams
Laboratory
UMR
Pathogenesis of vascular infections
Guillaume Dumenil
Laboratory
Dynamics of Host-Pathogen Interactions
Jost Enninga
Laboratory
Imaging and Modeling
Christophe Zimmer
Laboratory
Dynamics of Developmental Decisions in Drosophila
François Schweisguth
Laboratory
Cell Polarity, Migration And Cancer
Sandrine Etienne-Manneville
Laboratory
Human Evolutionary Genetics
Lluis Quintana-Murci
Laboratory
Structural Bioinformatics
Michael Nilges
Laboratory
Biological Image Analysis
Jean-Christophe Olivo-Marin
Laboratory
Heart Morphogenesis
Sigolène Meilhac
Group
Neural circuits for spatial navigation and memory
Christoph Schmidt-Hieber
Laboratory
Membrane Traffic and Pathogenesis
Chiara Zurzolo
Group
Group: Translation dependent mRNA degradation
Cosmin Saveanu
Laboratory
Spatial Regulation of Genomes
Romain Koszul
Laboratory
Zebrafish Neurogenetics
Laure Bally-Cuif
Laboratory
Auditory Therapies Innovation Lab
Christine Petit
Laboratory
Biochemistry of Macromolecular Interactions
Daniel Ladant
Platform
Molecular Biophysics
Patrick England
Laboratory
Stem Cells And Development
Shahragim Tajbakhsh
Laboratory
Bacterial Genome Plasticity
Didier Mazel
Laboratory
Synthetic Biology
David Bikard
Group
BiophysiCyaA
Alexandre Chenal
Laboratory
Dynamic Regulation of Morphogenesis
Jérôme Gros
Laboratory
InBio: Experimental and Computational Methods for Modeling Cellular Processes
Grégory Batt
Laboratory
Synapse and Circuit Dynamics
David DiGregorio
Laboratory
Neural Circuit Dynamics and Decision Making
Florent Haiss
Laboratory
Physical Microfluidics and Bioengineering
Charles Baroud
Laboratory
Cell death and epithelial homeostasis
Romain Levayer
Laboratory
Physics of Biological Function
Thomas Gregor
Laboratory
Decision and Bayesian Computation
Jean-Baptiste Masson
Qbio Symposia
• October 17th 2016: “Kick off meeting” of the Qbio program (Guillaume Duménil, Sven van Teeffelen)
• June 9th 2017: “Forces in Biology” (Romain Levayer, Nicolas Dray, Sandrine Etienne-Manneville, Patrick England, Alexandre Dufour).
• May 25th 2018: “Physics of Biological Membranes” (Thomas Wollert (IP), Patricia Bassereau (Curie))
• October 11-12 2018: “Neural networks – from machines to brains” (David Di Gregorio, JB Masson, and Christoph Schmidt-Hieber (IP), Rémi Monasson (ENS))
• January 2019: “Quantitative cell biology of bacteria“ (Guillaume Duménil, Sven van Teeffelen)
• June 2021: “Bridging the scales, from single cells, to populations, tissues and organs” (Charles Baroud, Romain Levayer)
• October 2021: “The physics of cancer” (Sandrine Etienne-Manneville, Romain Levayer, jointly with the Cancer intiative)
• December 2022: “MeMoDEvo: Mechanics, Morphogenesis, Development and Evolution” (Thibaut Brunet, Romain Levayer, Katja Heuer and Roberto Toro)
Contacts
If you wish to be informed by email please sign up on the Qbio@pasteur.fr mailing list. Connect to this address : https://email.pasteur.fr/ Go to the Settings menu then options and then groups and sign-in.
Quantitative biology at the Institut Pasteur
Many Pasteur laboratories are integrating physical approaches in their studies ranging from structural biology, via cell biology, to infection, neurobiology and development.
• Multiscale self-organization is studied at the level of protein machineries in bacteria, cytoskeleton during the migration of eucaryotic cells and organizaton of tissues during development.
• Cellular and tissue mechanics are explored during bacterial aggregation, grastrulation and heart development as well as during amoebae movement.
• Information processing and signaling are studied in the context of neurobiology, 3D genome architecture, transciption and cell decision making.
Objectives of the Qbio program at Institut Pasteur
The Quantitative Biology program aims to encourage these developments on campus. The major purpose of this program is:
• To foster interactions between scientists involved in Quantitative Biology at Institut Pasteur through seminars and mini-symposiums.
• To bring quantitatively trained scientists into biology
• To encourage biologists to integrate quantitative models into their research
Qbio progress reports
The Qbio programm organise monthly progress reports where early career scientists (PhD, postdoc) present ongoing projects at the interface between biology, physics and/or mathematics in an informal setting. The primary aim is to foster interactions on the campus. The meetings currently take place online on Thursdays at 2pm. Contact the organisers if you would like to join.
You will find the current programm below :
| March 11th | Presentation 1 | Assessing single-bacteria response to antibiotics (Andrey Aristov + Lena Le Quellec, Baroud Lab) |
| Presentation 2 | Modeling and efficient characterization of enzyme-mediated response to antibiotics (Virgile Andreani, InBio) | |
| April 15th | Presentation 1 | spatiotemporal dynamic of neural stem cell fate decisions (Nicolas Dray, Laure Bally-Cuif lab) |
| Presentation 2 | Laure Leblanc, Labo Duménil, Bacterial growth under confinement | |
| May 20th | Presentation 1 | Operant learning and multi armed bandit game playing with drosophila larva (Chloe barre, labo DBC) |
| Presentation 2 | From the embryonic heart loop to congenital heart defects (Audrey Desgrange, labo, SM) | |
| June 17th | Presentation 1 | Group David di Gregorio |
| Presentation 2 | Role of intermediate filaments in the mechanics of invading cells (Emma van Bodegraven, Labo PCMC) | |
| September 9th | Presentation 1 | Interdisciplinary characterization of DNA repair in yeast cells (Nadia Vertti-Quintero, Baroud lab) |
| Presentation 2 | Epithelial robustness is an emergening property of local ERK feedbacks driven by cell death (Léo Valon, group Romain Levayer) | |
| October 14th | Presentation 1 | Unsupervised learning of heterogenous random walks (Hippolyte Verdier, labo DBC) |
| Presentation 2 |
Pictures & Media
