How sensory information is processed and how it is modulated by other brain areas is a key question in systems neuroscience. The long-term goal of our research is to understand how neuronal networks in different parts of the brain interact during perception and how this interplay forms the basis of learning and decision-making. Using two and three-photon imaging, holography, multi electrode recordings, optogenetics, intracellular patch clamp recordings and psychophysics, we are investigating how cortical microcircuits interact to produce a behavioral output.
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Transversal Project
Publications
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2018Pupillary dilations of mice performing a vibrotactile discrimination task reflect task engagement and response confidence., bioRxiv 444919; doi: https://doi.org/10.1101/444919.
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2017Deviant Processing in the Primary Somatosensory Cortex, Cereb. Cortex 2017 Jan;27(1):863-876.
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2015Design and performance of an ultra-flexible two-photon microscope for in vivo research, Biomed Opt Express 2015 Nov;6(11):4228-37.
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2015Sparse, reliable, and long-term stable representation of periodic whisker deflections in the mouse barrel cortex, Neuroimage 2015 Jul;115:52-63.
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2014Tactile frequency discrimination is enhanced by circumventing neocortical adaptation, Nat. Neurosci. 2014 Nov;17(11):1567-73.
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2013Rhythmic whisking area (RW) in rat primary motor cortex: an internal monitor of movement-related signals?, J. Neurosci. 2013 Aug;33(35):14193-204.
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2012Reorganization of cortical population activity imaged throughout long-term sensory deprivation, Nat. Neurosci. 2012 Nov;15(11):1539-46.
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2012Novel two-alternative forced choice paradigm for bilateral vibrotactile whisker frequency discrimination in head-fixed mice and rats, J. Neurophysiol. 2013 Jan;109(1):273-84.
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2010The head-fixed behaving rat–procedures and pitfalls, Somatosens Mot Res 2010;27(4):131-48.
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2010Model-based feature construction for multivariate decoding, Neuroimage 2011 May;56(2):601-15.
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Pictures & Media
3D reconstruction of a somatosensory cortex neuron functionally imaged in-vivo and recorded and stained in-vitro.