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© Thomas Gregor
The image shows a Drosophila embryo 2 hr after fertilization, with nuclei at the surface fluorescently labeled for Bicoid protein (blue), Hunchback protein (green), and DNA (red). Using two-photon microscopy these embryos were imaged to quantitatively characterize the dynamics and precision of how morphogen molecules communicate positional information to individual nuclei. In this example, the shallow Bicoid gradient generates a sharp Hunchback boundary (enlarged in the background), partitioning the embryo in half. This input/output relationship is quantitatively represented in the foreground (yellow), where each dot specifies the Bicoid concentration (horizontal axis) and Hunchback concentration (vertical axis) measured in a single nucleus. The results indicate that the precision with which the embryo interprets and locates this boundary is very high, approaching limits set by simple physical principles.
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Transversal Projects

Quantitative biology

The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The […]

CV

  • 1999 Physics Master (Geneva University, Switzerland)
  • 2001 Chemistry Master (Princeton University)
  • 2005 Ph.D. Biophysics (Princeton University)
  • 2006-09 JSPS Fellow (University of Tokyo, Japan)
  • 2009 Assistant Professor of Physics (Princeton University)
  • 2015 Associate Professor of Physics (Princeton University)
  • 2018 Head of Structure (Institut Pasteur)
  • 2019 Professor of Physics (Princeton University)

Some background on career path can be found here:

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