Timeline
Gérald Spaeth
Head of Structure
04 Jun 2024
publication
Genomic and epidemiological evidence for the emergence of a L. infantum/L. donovani hybrid with unusual epidemiology in northern Italy.
Read more30 Oct 2023
event
DPT Parasites and Insects Vectors Seminar – Professor Eva GLUENZ “Dissecting gene function in Leishmania with CRISPR-Cas9 knockout screens”
Read more04 Sep 2023
event
PhD Thesis-Maria Gutiérrez-Sanchez: “Macrophage Lysine Demethylase LSD1: Implications for intracellular Leishmania survival and host-directed drug discovery”
Read more01 Aug 2023
event
DPT Parasites and Insects Vectors Extraordinary Seminar – Maria Adelaida GOMEZ “Treatment failure and persistent Leishmania infection: Shifting the paradigm from killing the bug to a healthy co-living”
Read more14 Apr 2023
event
DPT Parasites and Insects Vectors Seminar – Michael Barrett “Dissimilation of immunometabolites by Leishmania mexicana”
Read more07 Mar 2023
publication
Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage.
Read more01 Jan 2023
publication
Amphotericin B resistance correlates with increased fitness in vitro and in vivo in Leishmania (Mundinia) martiniquensis.
Read more18 Nov 2022
event
DPT Parasites and insects Vectors Seminar- Cyrille Botté “Membrane biogenesis, host-parasite interaction and apicomplexa parasite survival: It’s all about lipids!”
Read more15 Nov 2022
publication
Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance.
Read more04 Nov 2022
24 Aug 2022
publication
Retrospective Analysis of Leishmaniasis in Sicily (Italy) from 2013 to 2021: One-Health Impact and Future Control Strategies.
Read more08 Jul 2022
publication
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni.
Read more01 Mar 2022
01 Mar 2022
publication
Experimental evolution links post-transcriptional regulation to Leishmania fitness gain.
Read more10 Feb 2022
10 Feb 2022
project
Campus France – Franco-Thai Mobility Programme / PHC SIAM. Comparative genomic analysis and phenotypic drug screening of Leishmania martiniquensis and Leishmania orientalis, the parasites causing emerging leishmaniasis in Thailand.
Read more10 Feb 2022
project
Campus France – PRIX « TREMPLIN » DE COOPERATION BILATERALE EN RECHERCHE – AFRIQUE : Génomique comparative pour l’étude de l’épidémiologie et de l’expression clinique des leishmanioses causées par Leishmania infantum en Tunisie.
Read more10 Feb 2022
project
PTR 425 EvoLeish: Mapping mechanisms of evolutionary adaptation underlying fitness gain in New World L. infantum strains
Read more21 Dec 2021
publication
Genome instability drives epistatic adaptation in the human pathogen Leishmania.
Read more20 Dec 2021
publication
GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells.
Read more14 Dec 2021
publication
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.
Read more29 Apr 2021
29 Jan 2021
publication
Colonization and genetic diversification processes of Leishmania infantum in the Americas.
Read more15 Jan 2021
publication
In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.
Read more01 Jan 2021
publication
Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay.
Read more01 Jan 2021
publication
Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion.
Read more30 Nov 2020
publication
Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines.
Read more05 Oct 2020
01 Oct 2020
publication
Nuclear and mitochondrial genome sequencing of North-African Leishmania infantum isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype.
Read more22 Jun 2020
publication
Dynamic imaging reveals surface exposure of virulent Leishmania amastigotes during pyroptosis of infected macrophages.
Read more20 May 2020
publication
Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations.
Read more01 May 2020
publication
Leishmania dual-specificity tyrosine-regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype.
Read more20 Feb 2020
publication
SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani.
Read more11 Feb 2020
publication
Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response.
Read more03 Feb 2020
event
CANCELLED “Mechanisms of selective translation stimulation and suppression by the multiple eIF4E isoforms of Trypanosoma brucei” – Christine Clayton
Read more01 Jan 2020
publication
Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation.
Read more19 Dec 2019
publication
Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas.
Read more22 Aug 2019
event
PhD Defense – Daniel MARTEL -20th September 2019 at 9am: “Functional characterisation of Leishmania casein kinase 1.2 in the parasite and the mammalian host”
Read more09 Jul 2019
publication
Author Correction: Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening.
Read more25 Mar 2019
publication
Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity.
Read more14 Feb 2019
08 Feb 2019
24 Jan 2019
24 Jan 2019
publication
Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening.
Read more16 Jan 2019
project
International Mixed Unit ‘Inflammation and Leishmania infection’ (IMU-InflaLeish): Exploiting host-pathogen interaction for the discovery of novel anti-microbial drug targets and drug candidates.
Read more16 Jan 2019
16 Jan 2019
project
“Modelling and functional analysis of clonal Evolution in Leishmania – possible role of non-coding RNAs and RNA modification”
Read more08 Jan 2019
06 Nov 2018
publication
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification.
Read more24 Aug 2018
12 Apr 2018
publication
Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania
Read more01 Jan 2018
publication
Reverse Epidemiology: An Experimental Framework to Drive Leishmania Biomarker Discovery in situ by Functional Genetic Screening Using Relevant Animal Models.
Read more06 Nov 2017
publication
Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani
Read more23 May 2017
publication
Modulation of Aneuploidy in during Adaptation to Different and Environments and Its Impact on Gene Expression
Read more10 Apr 2017
publication
Old World cutaneous leishmaniasis challenges in Morocco, Algeria, Tunisia and Iran (MATI): a collaborative attempt to combat the disease
Read more23 Dec 2016
publication
Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth
Read more22 Sep 2016
publication
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor
Read more02 Jul 2016
publication
Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids.
Read more16 Jun 2016
publication
Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant
Read more01 May 2016
publication
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Read more20 Apr 2016
publication
Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania
Read more12 Mar 2016
publication
Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy
Read more10 Feb 2016
event
“Establishing a road map of the developmental program leading to infectivity in African trypanosomes”
Read more06 Jan 2016
event
“Trans-splicing and RNA modification regulate the life and death of Trypanosoma brucei”
Read more22 Oct 2015
publication
Implication of different domains of the Leishmania major metacaspase in cell death and autophagy
Read more14 Sep 2015
08 Sep 2015
project
ANR Patho-Methylome – The role of lysine methylation in host-pathogen interactions
Read more07 Sep 2015
07 Sep 2015
project
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Read more07 Sep 2015
project
LeiSHield – A new collaborative action to determine prevalence, anticipate emergence and assess urbanization of cutaneous and visceral leishmaniasis in LeishRIIP partner countries
Read more07 Sep 2015
project
ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening
Read more07 Sep 2015
project
ANR TranSig – Trans-signalling: A novel mechanism of Leishmania host cell immune evasion through the release of parasite signalling proteins
Read more07 Sep 2015
project
PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery
Read more07 Sep 2015
project
PTR 496 – Investigating the reciprocal relationship between macrophage inflammasome activity and intracellular Leishmania infection
Read more11 May 2015
09 May 2015
publication
Phosphoproteomic analysis of wild-type and antimony-resistant Leishmania braziliensis lines by 2D-DIGE technology
Read more08 Apr 2015
publication
A touch of Zen: post-translational regulation of the Leishmania stress response.
Read more31 Oct 2014
publication
Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process
Read more01 Jul 2014
publication
Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.
Read more23 May 2014
publication
The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status
Read more16 Apr 2014
publication
Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends
Read more01 Jan 2014
publication
Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.
Read more20 Dec 2013
publication
[Leishmania epidemiology, diagnosis, chemotherapy and vaccination approaches in the international network of Pasteur Institutes]
Read more16 Oct 2013
publication
Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism
Read more11 Jun 2013
publication
Phosphoproteomic analysis of differentiating Leishmania parasites reveals a unique stage-specific phosphorylation motif
Read more16 May 2013
publication
Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound.
Read more21 Dec 2012
publication
Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani.
Read more09 Aug 2012
publication
The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.
Read more21 Jun 2012
publication
CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation
Read more19 Dec 2011
publication
PhosTryp: a phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae
Read more21 Jul 2011
publication
Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery
Read more26 Apr 2011
publication
Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation
Read more21 Apr 2011
publication
Imaging host cell-Leishmania interaction dynamics implicates parasite motility, lysosome recruitment, and host cell wounding in the infection process
Read more26 Mar 2011
publication
Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani.
Read more01 Nov 2010
publication
Identification of Leishmania-specific protein phosphorylation sites by LC-ESI-MS/MS and comparative genomics analyses
Read more30 Jun 2010
29 Jun 2010
publication
Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.
Read more09 Jun 2010
publication
Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas
Read more19 Apr 2010
publication
Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage
Read more02 Oct 2009
publication
Leishmania major MPK7 protein kinase activity inhibits intracellular growth of the pathogenic amastigote stage
Read more23 Jul 2009
publication
A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection
Read more01 May 2009
17 Apr 2009
publication
A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major
Read more04 Feb 2009
publication
The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?
Read more19 Jul 2008
publication
Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice
Read more01 Jan 2008
12 Oct 2007
publication
Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken
Read more30 Mar 2007
publication
Over-expression of Leishmania major MAP kinases reveals stage-specific induction of phosphotransferase activity
Read more01 Oct 2004
publication
A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan
Read more01 Jun 2004
publication
Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies
Read more15 Mar 2004
publication
Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response
Read more01 Jan 2004
publication
Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani
Read more29 Aug 2003
17 Jul 2003
publication
The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts
Read more01 Oct 2001
publication
A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation
Read more01 May 2001
publication
Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species
Read more01 Aug 2000
publication
Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major
Read more01 Nov 1999
publication
Decreased capacity of recombinant 45/47-kDa molecules (Apa) of Mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern
Read more01 Nov 1999
publication
Deglycosylation of the 45/47-kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses
Read more23 Feb 1998
publication
Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells
Read more01 Apr 1997
publication
Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells
Read more01 Jan 1995
publication