Timeline

Gérald Spaeth
Head of Structure
22 Aug 2019
event

PhD Defense – Daniel MARTEL -20th September 2019 at 9am: “Functional characterisation of Leishmania casein kinase 1.2 in the parasite and the mammalian host”

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14 Feb 2019
team

Genetic and molecular basis of host-parasite interactions

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14 Feb 2019
project

Private: PTR 403 – Generation and validation of innovative tools for 2D- and 3D-real time imaging of trypanosomatid parasites in their mammalian hosts

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24 Jan 2019
project

H2020-MSA-RISE-2017: LeiSHield-MATI consortium

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24 Jan 2019
publication

Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening

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16 Jan 2019
project

International Mixed Unit ‘Inflammation and Leishmania infection’ (IMU-InflaLeish): Exploiting host-pathogen interaction for the discovery of novel anti-microbial drug targets and drug candidates.

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16 Jan 2019
project

“H2020-MSCA-RISE-2017: LeiSHield-MATI consortium”

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16 Jan 2019
project

“Modelling and functional analysis of clonal Evolution in Leishmania – possible role of non-coding RNAs and RNA modification”

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08 Jan 2019
event

“Leishmania: the art of living in a vacuole” – Albert DESCOTEAUX

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13 Dec 2018
publication

Drug Discovery for Kinetoplastid Diseases: Future Directions

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06 Nov 2018
publication

Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification

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19 Sep 2018
publication

Reverse Epidemiology: An Experimental Framework to Drive Biomarker Discovery by Functional Genetic Screening Using Relevant Animal Models

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24 Aug 2018
event

CRISPR in Parasitology Symposium

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12 Apr 2018
publication

Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania

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29 Nov 2017
publication

Characterisation of Casein Kinase 1.1 in Using the CRISPR Cas9 Toolkit

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06 Nov 2017
publication

Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani

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08 Jun 2017
publication

The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery

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23 May 2017
publication

Modulation of Aneuploidy in during Adaptation to Different and Environments and Its Impact on Gene Expression

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10 Apr 2017
publication

Old World cutaneous leishmaniasis challenges in Morocco, Algeria, Tunisia and Iran (MATI): a collaborative attempt to combat the disease

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23 Dec 2016
publication

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth

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22 Sep 2016
publication

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor

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02 Jul 2016
publication

Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids

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16 Jun 2016
publication

Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant

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22 Apr 2016
publication

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity

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20 Apr 2016
publication

Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania

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12 Mar 2016
publication

Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy

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10 Feb 2016
event

“Establishing a road map of the developmental program leading to infectivity in African trypanosomes”

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06 Jan 2016
event

“Trans-splicing and RNA modification regulate the life and death of Trypanosoma brucei”

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22 Oct 2015
publication

Implication of different domains of the Leishmania major metacaspase in cell death and autophagy

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14 Sep 2015
project

PTR 392 – Systems-wide analysis of Leishmania virulence

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08 Sep 2015
project

ANR Patho-Methylome – The role of lysine methylation in host-pathogen interactions

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07 Sep 2015
project

FP7 Anti-Parasitic Drug Discovery in Epigenetics (A-ParaDDisE)

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07 Sep 2015
project

FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)

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07 Sep 2015
project

LeiSHield – A new collaborative action to determine prevalence, anticipate emergence and assess urbanization of cutaneous and visceral leishmaniasis in LeishRIIP partner countries

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07 Sep 2015
project

ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening

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07 Sep 2015
project

ANR TranSig – Trans-signalling: A novel mechanism of Leishmania host cell immune evasion through the release of parasite signalling proteins

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07 Sep 2015
project

PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery

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07 Sep 2015
project

PTR 496 – Investigating the reciprocal relationship between macrophage inflammasome activity and intracellular Leishmania infection

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11 May 2015
team

Molecular Parasitology and Signaling

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09 May 2015
publication

Phosphoproteomic analysis of wild-type and antimony-resistant Leishmania braziliensis lines by 2D-DIGE technology

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08 Apr 2015
publication

A touch of Zen: post-translational regulation of the Leishmania stress response

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31 Oct 2014
publication

Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process

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18 Sep 2014
publication

Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability

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15 Sep 2014
department

Parasites and Insect Vectors

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03 Jun 2014
publication

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses

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23 May 2014
publication

The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status

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16 Apr 2014
publication

Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends

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23 Dec 2013
publication

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection

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20 Dec 2013
publication

[Leishmania epidemiology, diagnosis, chemotherapy and vaccination approaches in the international network of Pasteur Institutes]

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16 Oct 2013
publication

Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism

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11 Jun 2013
publication

Phosphoproteomic analysis of differentiating Leishmania parasites reveals a unique stage-specific phosphorylation motif

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16 May 2013
publication

Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound

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21 Dec 2012
publication

Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani

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09 Aug 2012
publication

The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms

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21 Jun 2012
publication

CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation

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19 Dec 2011
publication

PhosTryp: a phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae

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21 Jul 2011
publication

Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery

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26 Apr 2011
publication

Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation

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21 Apr 2011
publication

Imaging host cell-Leishmania interaction dynamics implicates parasite motility, lysosome recruitment, and host cell wounding in the infection process

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26 Mar 2011
publication

Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani

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01 Nov 2010
publication

Identification of Leishmania-specific protein phosphorylation sites by LC-ESI-MS/MS and comparative genomics analyses

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30 Jun 2010
publication

Probing the dynamic nature of signalling pathways by IMAC and SELDI-tof MS

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29 Jun 2010
publication

Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability

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09 Jun 2010
publication

Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas

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19 Apr 2010
publication

Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage

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02 Oct 2009
publication

Leishmania major MPK7 protein kinase activity inhibits intracellular growth of the pathogenic amastigote stage

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23 Jul 2009
publication

A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection

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01 May 2009
publication

Inflammation recapitulates the ontogeny of lymphoid stromal cells

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17 Apr 2009
publication

A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major

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04 Feb 2009
publication

The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?

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19 Jul 2008
publication

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice

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01 Jan 2008
publication

Phosphoproteomic analysis of Leishmania donovani pro- and amastigote stages

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12 Oct 2007
publication

Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken

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30 Mar 2007
publication

Over-expression of Leishmania major MAP kinases reveals stage-specific induction of phosphotransferase activity

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01 Oct 2004
publication

A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan

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01 Jun 2004
publication

Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies

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15 Mar 2004
publication

Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response

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01 Jan 2004
publication

Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani

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29 Aug 2003
publication

Persistence without pathology in phosphoglycan-deficient Leishmania major

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17 Jul 2003
publication

The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts

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01 Oct 2001
publication

A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation

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01 May 2001
publication

Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species

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01 Aug 2000
publication

Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major

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01 Nov 1999
publication

Decreased capacity of recombinant 45/47-kDa molecules (Apa) of Mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern

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01 Nov 1999
publication

Deglycosylation of the 45/47-kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses

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23 Feb 1998
publication

Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells

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01 Apr 1997
publication

Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells

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01 Jan 1995
publication

Expression of the complement C8 genes during interleukin-6-mediated in vitro induction of the acute-phase response

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