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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
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Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Probing the dynamic nature of signalling pathways by IMAC and SELDI-tof MS

Structural insights into serine-rich fimbriae from Gram-positive bacteria

Bloodstream Trypanosoma brucei cell

Publication : PLoS neglected tropical diseases

Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability

Team: Trypanosome Cell Biology

Team: Molecular Parasitology and Signaling

Member: Philippe Bastin

Member: Thierry Blisnick

Member: Gérald Spaeth

Member: Olivier Leclercq

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in PLoS neglected tropical diseases - 29 Jun 2010

Yau WL, Blisnick T, Taly JF, Helmer-Citterich M, Schiene-Fischer C, Leclercq O, Li J, Schmidt-Arras D, Morales MA, Notredame C, Romo D, Bastin P, Späth GF

Link to Pubmed [PMID] – 20614016

PLoS Negl Trop Dis 2010;4(6):e729

Cyclosporin A (CsA) has important anti-microbial activity against parasites of the genus Leishmania, suggesting CsA-binding cyclophilins (CyPs) as potential drug targets. However, no information is available on the genetic diversity of this important protein family, and the mechanisms underlying the cytotoxic effects of CsA on intracellular amastigotes are only poorly understood. Here, we performed a first genome-wide analysis of Leishmania CyPs and investigated the effects of CsA on host-free L. donovani amastigotes in order to elucidate the relevance of these parasite proteins for drug development.

http://www.ncbi.nlm.nih.gov/pubmed/20614016

Published on: 29 Jun 2010 • Modified on: 03 Sep 2015