Ligne de temps
Gérald Spaeth
Responsable de Structure
30 oct. 2023
event
DPT Parasites and Insects Vectors Seminar – Professor Eva GLUENZ “Dissecting gene function in Leishmania with CRISPR-Cas9 knockout screens”
Lire plus04 sept. 2023
event
PhD Thesis-Maria Gutiérrez-Sanchez: “Macrophage Lysine Demethylase LSD1: Implications for intracellular Leishmania survival and host-directed drug discovery”
Lire plus01 août 2023
event
DPT Parasites and Insects Vectors Extraordinary Seminar – Maria Adelaida GOMEZ “Treatment failure and persistent Leishmania infection: Shifting the paradigm from killing the bug to a healthy co-living”
Lire plus14 avr. 2023
event
DPT Parasites and Insects Vectors Seminar – Michael Barrett “Dissimilation of immunometabolites by Leishmania mexicana”
Lire plus07 mars 2023
publication
Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage.
Lire plus01 janv. 2023
publication
Amphotericin B resistance correlates with increased fitness in vitro and in vivo in Leishmania (Mundinia) martiniquensis.
Lire plus18 nov. 2022
event
DPT Parasites and insects Vectors Seminar- Cyrille Botté “Membrane biogenesis, host-parasite interaction and apicomplexa parasite survival: It’s all about lipids!”
Lire plus15 nov. 2022
publication
Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance.
Lire plus04 nov. 2022
24 août 2022
publication
Retrospective Analysis of Leishmaniasis in Sicily (Italy) from 2013 to 2021: One-Health Impact and Future Control Strategies.
Lire plus08 juil. 2022
publication
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni.
Lire plus01 mars 2022
01 mars 2022
publication
Experimental evolution links post-transcriptional regulation to Leishmania fitness gain.
Lire plus10 févr. 2022
10 févr. 2022
project
Campus France – Franco-Thai Mobility Programme / PHC SIAM. Comparative genomic analysis and phenotypic drug screening of Leishmania martiniquensis and Leishmania orientalis, the parasites causing emerging leishmaniasis in Thailand.
Lire plus10 févr. 2022
project
Campus France – PRIX « TREMPLIN » DE COOPERATION BILATERALE EN RECHERCHE – AFRIQUE : Génomique comparative pour l’étude de l’épidémiologie et de l’expression clinique des leishmanioses causées par Leishmania infantum en Tunisie.
Lire plus10 févr. 2022
project
PTR 425 EvoLeish: Mapping mechanisms of evolutionary adaptation underlying fitness gain in New World L. infantum strains
Lire plus21 déc. 2021
publication
Genome instability drives epistatic adaptation in the human pathogen Leishmania.
Lire plus20 déc. 2021
publication
GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells.
Lire plus14 déc. 2021
publication
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.
Lire plus29 avr. 2021
29 janv. 2021
publication
Colonization and genetic diversification processes of Leishmania infantum in the Americas.
Lire plus15 janv. 2021
publication
In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.
Lire plus01 janv. 2021
publication
Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion.
Lire plus01 janv. 2021
publication
Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay.
Lire plus30 nov. 2020
publication
Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines.
Lire plus05 oct. 2020
01 oct. 2020
publication
Nuclear and mitochondrial genome sequencing of North-African Leishmania infantum isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype.
Lire plus22 juin 2020
publication
Dynamic imaging reveals surface exposure of virulent Leishmania amastigotes during pyroptosis of infected macrophages.
Lire plus20 mai 2020
publication
Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations.
Lire plus01 mai 2020
publication
Leishmania dual-specificity tyrosine-regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype.
Lire plus20 févr. 2020
publication
SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani.
Lire plus11 févr. 2020
publication
Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response.
Lire plus03 févr. 2020
event
CANCELLED “Mechanisms of selective translation stimulation and suppression by the multiple eIF4E isoforms of Trypanosoma brucei” – Christine Clayton
Lire plus01 janv. 2020
publication
Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation.
Lire plus19 déc. 2019
publication
Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas.
Lire plus22 août 2019
event
PhD Defense – Daniel MARTEL -20th September 2019 at 9am: “Functional characterisation of Leishmania casein kinase 1.2 in the parasite and the mammalian host”
Lire plus09 juil. 2019
publication
Author Correction: Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening.
Lire plus25 mars 2019
publication
Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity.
Lire plus14 févr. 2019
08 févr. 2019
24 janv. 2019
24 janv. 2019
publication
Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening.
Lire plus16 janv. 2019
project
International Mixed Unit ‘Inflammation and Leishmania infection’ (IMU-InflaLeish): Exploiting host-pathogen interaction for the discovery of novel anti-microbial drug targets and drug candidates.
Lire plus16 janv. 2019
16 janv. 2019
project
“Modelling and functional analysis of clonal Evolution in Leishmania – possible role of non-coding RNAs and RNA modification”
Lire plus08 janv. 2019
06 nov. 2018
publication
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification.
Lire plus24 août 2018
12 avr. 2018
publication
Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania
Lire plus01 janv. 2018
publication
Reverse Epidemiology: An Experimental Framework to Drive Leishmania Biomarker Discovery in situ by Functional Genetic Screening Using Relevant Animal Models.
Lire plus06 nov. 2017
publication
Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani
Lire plus23 mai 2017
publication
Modulation of Aneuploidy in during Adaptation to Different and Environments and Its Impact on Gene Expression
Lire plus10 avr. 2017
publication
Old World cutaneous leishmaniasis challenges in Morocco, Algeria, Tunisia and Iran (MATI): a collaborative attempt to combat the disease
Lire plus23 déc. 2016
publication
Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth
Lire plus22 sept. 2016
publication
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor
Lire plus02 juil. 2016
publication
Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids.
Lire plus16 juin 2016
publication
Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant
Lire plus01 mai 2016
publication
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Lire plus20 avr. 2016
publication
Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania
Lire plus12 mars 2016
publication
Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy
Lire plus10 févr. 2016
event
“Establishing a road map of the developmental program leading to infectivity in African trypanosomes”
Lire plus06 janv. 2016
event
“Trans-splicing and RNA modification regulate the life and death of Trypanosoma brucei”
Lire plus22 oct. 2015
publication
Implication of different domains of the Leishmania major metacaspase in cell death and autophagy
Lire plus14 sept. 2015
08 sept. 2015
project
ANR Patho-Methylome – The role of lysine methylation in host-pathogen interactions
Lire plus07 sept. 2015
07 sept. 2015
project
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Lire plus07 sept. 2015
project
LeiSHield – A new collaborative action to determine prevalence, anticipate emergence and assess urbanization of cutaneous and visceral leishmaniasis in LeishRIIP partner countries
Lire plus07 sept. 2015
project
ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening
Lire plus07 sept. 2015
project
ANR TranSig – Trans-signalling: A novel mechanism of Leishmania host cell immune evasion through the release of parasite signalling proteins
Lire plus07 sept. 2015
project
PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery
Lire plus07 sept. 2015
project
PTR 496 – Investigating the reciprocal relationship between macrophage inflammasome activity and intracellular Leishmania infection
Lire plus11 mai 2015
09 mai 2015
publication
Phosphoproteomic analysis of wild-type and antimony-resistant Leishmania braziliensis lines by 2D-DIGE technology
Lire plus08 avr. 2015
publication
A touch of Zen: post-translational regulation of the Leishmania stress response.
Lire plus31 oct. 2014
publication
Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process
Lire plus01 juil. 2014
publication
Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.
Lire plus23 mai 2014
publication
The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status
Lire plus16 avr. 2014
publication
Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends
Lire plus01 janv. 2014
publication
Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.
Lire plus20 déc. 2013
publication
[Leishmania epidemiology, diagnosis, chemotherapy and vaccination approaches in the international network of Pasteur Institutes]
Lire plus16 oct. 2013
publication
Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism
Lire plus11 juin 2013
publication
Phosphoproteomic analysis of differentiating Leishmania parasites reveals a unique stage-specific phosphorylation motif
Lire plus16 mai 2013
publication
Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound.
Lire plus21 déc. 2012
publication
Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani.
Lire plus09 août 2012
publication
The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.
Lire plus21 juin 2012
publication
CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation
Lire plus19 déc. 2011
publication
PhosTryp: a phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae
Lire plus21 juil. 2011
publication
Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery
Lire plus26 avr. 2011
publication
Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation
Lire plus21 avr. 2011
publication
Imaging host cell-Leishmania interaction dynamics implicates parasite motility, lysosome recruitment, and host cell wounding in the infection process
Lire plus26 mars 2011
publication
Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani.
Lire plus01 nov. 2010
publication
Identification of Leishmania-specific protein phosphorylation sites by LC-ESI-MS/MS and comparative genomics analyses
Lire plus30 juin 2010
29 juin 2010
publication
Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.
Lire plus09 juin 2010
publication
Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas
Lire plus19 avr. 2010
publication
Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage
Lire plus02 oct. 2009
publication
Leishmania major MPK7 protein kinase activity inhibits intracellular growth of the pathogenic amastigote stage
Lire plus23 juil. 2009
publication
A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection
Lire plus01 mai 2009
17 avr. 2009
publication
A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major
Lire plus04 févr. 2009
publication
The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?
Lire plus19 juil. 2008
publication
Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice
Lire plus01 janv. 2008
12 oct. 2007
publication
Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken
Lire plus30 mars 2007
publication
Over-expression of Leishmania major MAP kinases reveals stage-specific induction of phosphotransferase activity
Lire plus01 oct. 2004
publication
A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan
Lire plus01 juin 2004
publication
Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies
Lire plus15 mars 2004
publication
Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response
Lire plus01 janv. 2004
publication
Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani
Lire plus29 août 2003
17 juil. 2003
publication
The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts
Lire plus01 oct. 2001
publication
A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation
Lire plus01 mai 2001
publication
Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species
Lire plus01 août 2000
publication
Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major
Lire plus01 nov. 1999
publication
Decreased capacity of recombinant 45/47-kDa molecules (Apa) of Mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern
Lire plus01 nov. 1999
publication
Deglycosylation of the 45/47-kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses
Lire plus23 févr. 1998
publication
Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells
Lire plus01 avr. 1997
publication
Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells
Lire plus01 janv. 1995
publication