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© Research
Event

“Establishing a road map of the developmental program leading to infectivity in African trypanosomes”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
17
Mar 2016
Time
12:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: Lwoff Room: Retrovirus
Location
2016-03-17 12:00:00 2016-03-17 13:00:00 Europe/Paris “Establishing a road map of the developmental program leading to infectivity in African trypanosomes” Christian TSCHUDI – Yale University, School of Public Health (New Haven, USA) One of the fundamental steps in the life of a pathogen is the acquisition of infectivity. In the case of African trypanosomes, […] Institut Pasteur, Rue du Docteur Roux, Paris, France Gérald Spaeth gerald.spaeth@pasteur.fr

About

Tschudi_BISChristian TSCHUDIYale University, School of Public Health (New Haven, USA)

One of the fundamental steps in the life of a pathogen is the acquisition of infectivity. In the case of African trypanosomes, this occurs in the tsetse fly. Although the intricate nature of trypanosome development in the fly has been recognized for more than a century, the molecular mechanisms are still mysterious, due to experimental challenges of studying parasites in the fly. By overexpressing a single RNA-binding protein (RBP6) in non-infectious trypanosomes, we recapitulated in vitro the events leading to acquisition of infectivity in tsetse. The in vitro process opens numerous research avenues that will further our understanding how the pathogen becomes infectious and, further down the road, will provide an opening for new intervention strategies.

Site web du laboratoire : http://publichealth.yale.edu/people/christian_tschudi.profile

Contact : Gerald SPAETH (gerald.spaeth@pasteur.fr – 38.58)

Location

Building: Lwoff
Room: Retrovirus
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France