One of the fundamental steps in the life of a pathogen is the acquisition of infectivity. In the case of African trypanosomes, this occurs in the tsetse fly. Although the intricate nature of trypanosome development in the fly has been recognized for more than a century, the molecular mechanisms are still mysterious, due to experimental challenges of studying parasites in the fly. By overexpressing a single RNA-binding protein (RBP6) in non-infectious trypanosomes, we recapitulated in vitro the events leading to acquisition of infectivity in tsetse. The in vitro process opens numerous research avenues that will further our understanding how the pathogen becomes infectious and, further down the road, will provide an opening for new intervention strategies.
Site web du laboratoire : http://publichealth.yale.edu/people/christian_tschudi.profile
Contact : Gerald SPAETH (email@example.com – 38.58)