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© Research
Publication : Experimental parasitology

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice

Member: Gérald Spaeth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Experimental parasitology - 19 Jul 2008

Späth GF, McDowell MA, Beverley SM

Link to Pubmed [PMID] – 18682252

Exp. Parasitol. 2008 Nov;120(3):275-9

Protozoan parasites of the genus Leishmania escape from the immune response by interfering with signal transduction pathways of its host cell, the macrophage, thereby establishing permissive conditions for intracellular survival. Inhibition of macrophage activation after Leishmania infection has been suggested to require activation of the host cell phosphatase SHP-1. However, by utilizing infections of SHP-1 deficient (me(v)) and CD45 null mutant mice or macrophages, we provide evidence that intracellular survival of Leishmania major is not generally dependent on these cellular phosphatases.