Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Scientific Fields
Diseases
Organisms
Applications
Technique

About

All host/pathogen interactions rely on a constant co-evolutionary battle between genetically highly diverse microbial populations that infect equally diverse human or animal populations, with fitness gains selected both in pathogen and host through complex genotype-genotype interactions. The protozoan parasite Leishmania perfectly well illustrates this genetic cross-talk, with frequent phenotypic shifts (in pathogenicity, drug susceptibility or tissue tropism) selected in Leishmania field isolates through interactions with their heterogeneous vertebrate hosts, which in return react with very diverse clinical responses ranging from asymptomatic infection to fatal immunopathology. Despite the relevance of this highly dynamic host/pathogen relationship for disease outcome and parasite evolution, its underlying molecular mechanisms and physiological consequences remain poorly understood. To address these open questions, our team has initiated over recent years an important thematic transition from its past focus on molecular analysis of parasite signaling to its current and future focus on systems level analysis of Leishmania/macrophage interaction. This new focus animates the projects of three sub-teams that investigate (i) mechanisms of Leishmania evolutionary adaptation and fitness gain at genomic, transcriptomic and translational levels in culture, in animals (sand fly and hamster) and clinical infection (Axis 1), (ii) how Leishmania interferes in trans with macrophage functions through the exosomal release of parasite signaling proteins (Axis 2), and (iii) how Leishmania subverts macrophage immuno-metabolic functions on epigenetic and transcriptional levels to establish permissive conditions for intracellular infection (Axis 3).

Members

Former Members

PostDocs:        Suzanne Lamotte (2018 – 2019), Sima Drini (2016 – 2017), Penny Smirlis (2015 – 2017), Mathieu Cayla (2014 – 2015), Mariko Dacher (2012 -2014), Najma Rachidi (2011 – 2015), Wai-Lok Yau (2011 – 2012), Dirk Schmidt-Arras (2007 – 2010), Claire Forestier (2005 – 2008), Miguel Morales (2003 – 2011)

PhD students:   Director/co-Director of thesis: Laura Piel (2015 – 2020), Daniel Martel (2015 – 2019), Suzanne Lamotte (2014 – 2018), Sima Drini (2012 – 2016), Mathieu Cayla (2010 – 2014), Mariko Dacher (2008 -2012), Wai-Lok Yau (2009 – 2012)

M2 students:     Thibault Rosazza (2018/19), Marie Ajavon (2018), Candide Dossa (2018), Adrien Blisnick (2014), Franck Dumetz (2012), Amel Abdelkarim (2010)

Trainees:          Ihcen Kheraci, IP Algers (RIIP* fellow, 3 months 2019); Rafik Garni (RIIP* fellow, 3 months 2019); Arezou Lari, IP Iran (RIIP fellow, 3 months 2019); Farideh Bahari, IP Iran (RIIP* fellow, 3 months 2019); Mariana Boté-Cortes, Fiocruz Brazil (RIIP* visiting fellow, 3 months in 2017); Kyungwa Baek, IP Korea (RIIP fellow, 3 months, 2017); Kossiwa Kokou, IPShanghai (RIIP fellow, 3 months 2016); Evi Gouzelou, Hellenic Pasteur Institute (RIIP trainee, 4 months, 2015); Penny Smirlis, Hellenic Pasteur Institute (EU COST fellow, 1 month, 2015); Joo Hwan No, IP Korea (RIIP fellow, 1 month, 2014); Aymen Bali, (RIIP visiting fellow, 4 months, 2014); Penny Smirlis, Hellenic Pasteur Institute (RIIP trainee, 4 months, 2013); Grace Tewkesbury, Duke University (summer intern Pasteur Foundation, 2 months, 2013); Naouel Eddaikra, IP Alger (RIIP trainee, 1 month, 2013); Monica Gardner, IP Montevideo (RIIP trainee, 2 months, 2012); Sofia Horjales, IP Montevideo (RIIP trainee, 1 month, 2012); Stewart Pine, Harvard University (summer intern, 2 months, 2012); Samin Houshyar, MIT (summer intern, 2 months, 2011); Analia Lima, IP Montevideo (RIIP trainee, 3 months, 2011); Juan-Roman Luque-Ortega, CSIC Madrid (EMBO fellow, 2010); Sylvane Murta, Fiocruz Brazil, (RIIP fellow, 4 months, 2010); Nathalie Joli (summer intern, 1 month, 2010); Najiha Bilal Farooqi (International Fellow, Aga Khan University Medical College, Karachi, Pakistan, 2 months, 2010); Fatma Guerfali, IP Tunis (RIIP trainee, 3 months in 2009); Tahereh Taheri, IP Iran (RIIP trainee, 3 months, 2008), Elahe Davarpanah, IP Iran (RIIP trainee, 3 months in 2022), Ikram Maatallah, IP Morocco (RIIP trainee, 3 months in 2022)

Projects

Transversal Project

Equipments

Fundings

Publications

Download

Trainees

Mariana Boté-Cortes, Fiocruz Brazil (RIIP visiting fellow, 3 months in 2017); Kyungwa Baek, IP Korea (RIIP fellow, 3 months, 2017); Kossiwa Kokou, IPShanghai (RIIP fellow, 3 months 2016); Evi Gouzelou, Hellenic Pasteur Institute (RIIP trainee, 4 months, 2015); Penny Smirlis, Hellenic Pasteur Institute (EU COST fellow, 1 month, 2015); Joo Hwan No, IP Korea (RIIP fellow, 1 month, 2014); Aymen Bali, (RIIP visiting fellow, 4 months, 2014); Penny Smirlis, Hellenic Pasteur Institute (RIIP trainee, 4 months, 2013); Grace Tewkesbury, Duke University (summer intern Pasteur Foundation, 2 months, 2013); Naouel Eddaikra, IP Alger (RIIP trainee, 1 month, 2013); Monica Gardner, IP Montevideo (RIIP trainee, 2 months, 2012); Sofia Horjales, IP Montevideo (RIIP trainee, 1 month, 2012); Stewart Pine, Harvard University (summer intern, 2 months, 2012); Samin Houshyar, MIT (summer intern, 2 months, 2011); Analia Lima, IP Montevideo (RIIP trainee, 3 months, 2011); Juan-Roman Luque-Ortega, CSIC Madrid (EMBO fellow, 2010); Sylvane Murta, Fiocruz Brazil, (RIIP fellow, 4 months, 2010); Nathalie Joli (summer intern, 1 month, 2010); Najiha Bilal Farooqi (International Fellow, Aga Khan University Medical College, Karachi, Pakistan, 2 months, 2010); Fatma Guerfali, IP Tunis (RIIP trainee, 3 months in 2009); Tahereh Taheri, IP Iran (RIIP trainee, 3 moths, 2008).

Contact

  • Phone: +33 1 40 61 38 58
  • Email: gerald.spaeth@pasteur.fr
  • Address: 25 – 28 Rue du Docteur Roux, 75015 Paris, France