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© Research
Publication : Experimental and clinical immunogenetics

Expression of the complement C8 genes during interleukin-6-mediated in vitro induction of the acute-phase response

Member: Gérald Spaeth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Experimental and clinical immunogenetics - 01 Jan 1995

Späth GF, Ramadori G, Rittner C, Schneider PM

Link to Pubmed [PMID] – 7710765

Exp. Clin. Immunogenet. 1995;12(1):53-60

The three chains of the human complement component C8-alpha, beta and gamma- are encoded by distinct structural genes. C8A and C8B are closely linked on chromosome 1p and C8G is located on chromosome 9q. The biosynthesis and regulation of the gene products were studied in the human hepatoma-derived cell line HepG2 after in vitro induction of the acute-phase response by incubation with the cytokine interleukin IL-6. Analysis of C8 expression by immunoprecipitation and SDS-PAGE of biosynthetically labeled alpha-gamma and beta subunits demonstrated a positive response to this cytokine. The expression pattern observed in the hepatoma cells characterizes C8 in vitro as a positive acute-phase protein. In addition, the comparison of the relative amounts of the C8 transcripts provides evidence for a post transcriptional regulation of the C8 beta subunit. No evidence was obtained for an increased expression of IL-6 or IL-6 receptor mRNA thus excluding autoregulatory mechanisms of the cytokine in HepG2 cells.