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© Research
Publication : Trends in parasitology

Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species

Member: Gérald Spaeth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in parasitology - 01 May 2001

Turco SJ, Späth GF, Beverley SM

Link to Pubmed [PMID] – 11323305

Trends Parasitol. 2001 May;17(5):223-6

Lipophosphoglycan is a prominent member of the phosphoglycan-containing surface glycoconjugates of Leishmania. Genetic tests enable confirmation of its role in parasite virulence and permit discrimination between the roles of lipophosphoglycan and related glycoconjugates. When two different lipophosphoglycan biosynthetic genes from Leishmania major were knocked out, there was a clear loss of virulence in several steps of the infectious cycle but, with Leishmania mexicana, no effect on virulence was found. This points to an unexpected diversity in the reliance of Leishmania species on virulence factors, a finding underscored by recent studies showing great diversity in the host response to Leishmania species.