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© Jean-Claude Antoine
Leishmania mexicana amazonensis
Publication : ACS infectious diseases

Drug Discovery for Kinetoplastid Diseases: Future Directions.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in ACS infectious diseases - 08 Feb 2019

Rao SPS, Barrett MP, Dranoff G, Faraday CJ, Gimpelewicz CR, Hailu A, Jones CL, Kelly JM, Lazdins-Helds JK, Mäser P, Mengel J, Mottram JC, Mowbray CE, Sacks DL, Scott P, Späth GF, Tarleton RL, Spector JM, Diagana TT,

Link to Pubmed [PMID] – 30543391

Link to DOI – 10.1021/acsinfecdis.8b00298

ACS Infect Dis 2019 02; 5(2): 152-157

Kinetoplastid parasites have caused human disease for millennia. Significant achievements have been made toward developing new treatments for leishmaniasis (particularly on the Indian subcontinent) and for human African trypanosomiasis (HAT). Moreover, the sustained decrease in the incidence of HAT has made the prospect of elimination a tantalizing reality. Despite the gains, no new chemical or biological entities to treat kinetoplastid diseases have been registered in more than three decades, and more work is needed to discover safe and effective therapies for patients with Chagas disease and leishmaniasis. Advances in tools for drug discovery and novel insights into the biology of the host-parasite interaction may provide opportunities for accelerated progress. Here, we summarize the output from a gathering of scientists and physicians who met to discuss the current status and future directions in drug discovery for kinetoplastid diseases.

https://pubmed.ncbi.nlm.nih.gov/30543391